Korean J Obstet Gynecol.  2001 Dec;44(12):2236-2242.

The relationship between T869C polymorphism of transforming growth factor- 1 (TGF- 1) gene and bone mineral density in postmenopausal Korean women

• Kim JG
• Kim SH
• Choi YM
• Moon SY
• Lee JY

Abstract

OBJECTIVE
To investigate the relationship between the T869C polymorphism of transforming growth factor- 1 (TGF- 1) gene, serum TGF- 1 levels and bone mineral density (BMD) in postmenopausal Korean women.
METHODS
The T869C polymorphism of TGF- 1 gene was analyzed by allele specific polymerase chain reaction (PCR) and electrophoresis in 296 postmenopausal Korean women. Serum bone alkaline phosphatase (BAP), CrossLaps (CTX), and TGF- 1 were measured by immunoassay, and enzyme linked immunosorbent assay respectively. BMD at the lumbar spine and proximal femur was determined by dual energy X-ray absorptiometry.
RESULTS
The frequencies of the TT, TC, and CC genotypes of the T869C polymorphism were 3.3%, 93.7%, and 2.3%. There were no significant differences in BMD of the lumbar spine and proximal femur or serum BAP and CTX levels across the three TGF- 1 genotypes. No significant differences in the distribution of TGF- 1 genotypes and serum TGF- 1 levels among normal, osteopenic, and osteoporotic postmenopausal women were observed. There was no relationship between serum TGF- 1 levels and BMD at the lumbar spine and proximal femur.
CONCLUSIONS
The T869C polymorphism of TGF- 1 gene is not associated with serum TGF- 1 levels and BMD in postmenopausal Korean women.

Keyword

Postmenopausal women; TGF- 1; T869C polymorphism; BMD

MeSH Terms

Absorptiometry, Photon
Alkaline Phosphatase
Alleles
Bone Density*
Electrophoresis
Enzyme-Linked Immunosorbent Assay
Female
Femur
Genotype
Humans
Immunoassay
Polymerase Chain Reaction
Spine
Alkaline Phosphatase