Korean J Obstet Gynecol.  2000 Jun;43(6):1114-1118.

A Case Report of Vertebral Artery Aneurysm and Preeclampsia Complicating a Pregnancy with Neurofibromatosis

• Oh YM
• Koh MS
• Yeu JE
• Park CS
• Cho SJ

Abstract

Neurofibromatosis is a complex hereditary disease involving many organs and systems. The incidence in pregnancy is less frequent and has been reported as 1/5000 to 1/18500 deliveries. Therefore, little is known about the interactions between neurofibromatosis and pregnancy. A survey of relevant literature suggests that patients with NF have an increased risk of perinatal complications (pregnancy induced hypertension, IUGR, preterm labor, abortion, stillbirth, high cesarean section rate) and maternal disease aggravation (rupture of an aneurysm, sarcomatous degeneration of neurofibroma, activation of pheochromocytoma). Refined ultrasound, flow studies and fetal monitoring allow us to provide improved pregnancy care for neurofibromatosis. However, It should be remembered that even now, neurofibromatosis places pregnant women and their fetuses in a high risk group with the potential to develop life threatening complications. We report a case of vertebral artery aneurysm and preeclampsia complicating a pregnancy with neurofibromatosis."

Keyword

neurofibromatosis; aneurysm; preeclampsia

MeSH Terms

Aneurysm*
Cesarean Section
Female
Fetal Growth Retardation
Fetal Monitoring
Fetus
Genetic Diseases, Inborn
Humans
Hypertension
Incidence
Neurofibroma
Neurofibromatoses*
Neurofibromatosis 1
Obstetric Labor, Premature
Pre-Eclampsia*
Pregnancy*
Pregnant Women
Stillbirth
Ultrasonography
Vertebral Artery*