Korean J Obstet Gynecol.  1999 Oct;42(10):2264-2269.

Expression of p53 and MDM-2 Protein in Cervical Neoplasia

Abstract


OBJECTIVES
MDM-2 is an oncoprotein that inhibits p53 tumor suppressor protein. Amplication and over- expression of its protein have been observed in human malignancies, and these abnormalities have a role in tumorigenesis through inactivation of p53 function. To elucidate the role of p53 and MDM-2 protein in cervical neoplasia we investigated the expression rates of MDM-2 and p53 protein in surgically resected specimens. METHEDS: Immunohistochemical studies using anti-p53 and anti-MDM-2 protein in the paraffin embedded section of 62 cases including cervical intraepithelial neoplasm(CIN) and invasive cervical cancer were performed.
RESULTS
Expression rates of p53 protein were 25% in CIN I& CINII, 20% in CINIII, and 44% in invasive carcinoma, respectively. The MDM-2 protein were 33% in CIN I & CIN II, 16% in CIN III, and 48% in invasive carcinoma, respectively. There was no evident correlation between p53 positivity and MDM-2 positivity(p>0.05). However, correlation between MDM-2 negativity and p53 negativity was statistically significant(p=0.002)
CONCLUSION
These data suggest that the expression of p53 protein is presumed to be necessarily correlated with MDM-2 protein expression in cervical neoplasia.

Keyword

Cervical neoplasia; p53 protein; MDM-2 protein; p53; MDM-2

MeSH Terms

Carcinogenesis
Humans
Paraffin
Proto-Oncogene Proteins c-mdm2*
Tumor Suppressor Protein p53
Uterine Cervical Neoplasms
Paraffin
Proto-Oncogene Proteins c-mdm2
Tumor Suppressor Protein p53
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