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Role of Loss of O(6)-Methylguanine DNA Methyltransferase (MGMT) Expression in Non-Small Cell Lung Carcinomas (NSCLCs): with Reference to the Relationship with p53 Overexpression

Myong NH

  • KMID: 2165964
  • Cancer Res Treat.
  • 2010 Jun;42(2):95-100.
PURPOSE: Functional inactivation of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene has been demonstrated as loss of MGMT protein and suggested that it plays an important role in primary human neoplasia, including...
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Expression of Claudin-1, p53 and E-cadherin in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma of the Head and Neck

Choi KH, Lim JH, Lee JH, Kwon KS, Lee H, Park HS, Chung MJ, Moon WS, Eun JS, Lee DG, Jang KY

  • KMID: 1163217
  • Korean J Pathol.
  • 2008 Oct;42(5):287-293.
BACKGROUND: Pseudoepitheliomatous hyperplasia (PEH) is a reactive proliferation of surface epithelium and can be confused with invasive squamous cell carcinoma (SCC) in head and neck biopsy specimens. To distinguish PEH...
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Regulation of p53 Genes by Ferritin Light Chain: Preliminary Study

Yi SY

No abstract available in English.
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The Clinical Significance of Transforming Growth Factor (TGF) beta1, TGF beta Receptor beta II, p53 Protein and K-ras Point Mutation in Pancreatic Cancer

Kim KS, Chae YS, Kim JT

  • KMID: 2211144
  • J Korean Surg Soc.
  • 2008 Apr;74(4):274-281.
PURPOSE: Many cancers, including pancreatic cancer, harbor defects in TGF beta signaling and are resistant to TGF beta mediated growth inhibition. In addition, the expression of the p53 gene and...
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Genetic Expression Pattern of Gastric Carcinomas According to Cellular Mucin Phenotypes

Lee WA, Suh IS, Li YH, Eum JH, Yu WS, Bae HI

  • KMID: 1521624
  • Korean J Pathol.
  • 2007 Oct;41(5):307-315.
BACKGROUND: Gastric carcinomas (GCs) have recently been reclassified according to the mucin phenotypes. We aimed to characterize the relationship between the mucin phenotypes and the genetic alterations or the clinicopathologic...
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p53 Mutation and p53 Protein Expression in Gastric Cancer Tissues

Ku KB, Park SH, Chung HY, Yu W, Lee MH

  • KMID: 2211067
  • J Korean Surg Soc.
  • 2007 Apr;72(4):283-289.
PURPOSE: Variable changes occur in the progression from normal gastric epithelium to cancer, including many tumor, tumor suppressor and DNA repair genes, as well as growth factor and its receptors....
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Expression of Mutant p53 Protein, p21(waf1/cip1) and Cyclin D1 in Dysplasia and Adenocarcinoma of Stomach

Yun KJ, Kim HS, Jo HJ, Choi SC

  • KMID: 2304817
  • Korean J Gastrointest Endosc.
  • 2007 Jan;34(1):9-13.
BACKGROUND/AIMS: Gastric carcinoma is a major cause of morbidity and mortality in Korea. It evolves through dysplasia to an invasive adenocarcinoma. The carcinogenesis of dysplasia and adenocarcinoma in the stomach...
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Expression of Survivin in Non-Small Cell Lung Carcinoma: Relationship to Tumor Biology and Prognosis in Surgically Treated Patients

Jung MJ, Chun BK

  • KMID: 1598089
  • Korean J Pathol.
  • 2005 Jun;39(3):151-157.
BACKGROUND: Survivin, a novel member of inhibitor-of-apoptosis, is undetectable in most terminally differentiated nonproliferative adult tissue, but is overexpressed in some human malignancies. The survivin gene expression is repressed by...
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Expression of p53 Protein and Gene in Human Cholesteatoma

Jung JY, Kim KR, Yu SM, Hong SH, Chung WH, Kim HJ, Cho YS

  • KMID: 2276331
  • Korean J Otolaryngol-Head Neck Surg.
  • 2005 Jan;48(1):18-23.
BACKGROUND AND OBJECTIVES: Migration, hyperproliferation, differentiation of basal keratinocytes and accumulation of keratin debris are the major pathogenic reactions in middle ear cholesteatoma. p53 is a multi-functional protein that acts...
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The Expression of c-myc, bcl-2 and p53 Proteins in Adenocarcinomas of Lung

Yoo J, Jung JH, Choi HJ, Kang SJ, Kang CS

  • KMID: 2127915
  • Cancer Res Treat.
  • 2004 Apr;36(2):146-150.
PURPOSE: c-myc, bcl-2 and p53 are known to regulate apoptosis. There has been growing interest in analyzing their contribution to the pathogenesis and prognosis in a variety of human cancers....
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Detection of Epstein-Barr Virus by PCR and Expression of LMP1, p53, CD44 in Gastric Cancer

Lee MA, Hong YS, Kang JH, Lee KS, You JY, Lee KY, Park CH

  • KMID: 759684
  • Korean J Intern Med.
  • 2004 Mar;19(1):43-47.
BACKGROUND: Epstein-Barr virus (EBV) is associated with various lymphoproliferative disorders and nasopharyngeal carcinoma. Recently, some gastric cancer cells were observed to contain the EBV sequence. We detected EBV in gastric...
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Serum Anti-p53 Antibodies and p53 Protein Expression and Their Prognostic Relevance in Patients with Gastric Cance

Oh SH, Choi JC, Park TS, Kim HH, Lee EY, Kim HY, Sol MY

  • KMID: 2239112
  • Korean J Lab Med.
  • 2004 Feb;24(1):15-21.
BACKGROUND: Several cancer patients have developed antibodies that recognize the overexpressed p53 protein. In some tumor types, the presence of these antibodies is associated with a poor prognosis. Gastric cancer...
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The Clinical Features and Immunoreactivities of p53 and cox-2 in Malignant Meningiomas

Jeong IH, Jung S, Kang SS, Kim IY

  • KMID: 2339769
  • J Korean Neurosurg Soc.
  • 2003 Dec;34(6):521-525.
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Correlation between p53 and Rb Protein Expression and Clinicopathologic Features in Hepatocellular Carcinoma

Gu MJ, Choi JH

  • KMID: 1972873
  • Cancer Res Treat.
  • 2003 Dec;35(6):514-520.
PURPOSE: Hepatocellular carcinomas (HCC) are one of the most common cancers in Korea. The mechanism of HCC development is still unclear, and the aberration of the tumor suppressor genes in...
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Clinical Implications of VEGF and p53 Expression in Squamous Cell Carcinoma of the Cervix Treated with Radiation Therapy

Kang JO, Hong SE, Kang DW

  • KMID: 2166162
  • Cancer Res Treat.
  • 2003 Oct;35(5):440-444.
PURPOSE: The present study was designed to analyze the relationship between vascular endothelial growth factor (VEGF) and p53, and their impact on clinical outcome in squamous cell carcinoma of the...
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The Prognostic Significance of Immunohistochemically Detected Isolated Tumor Cells in Lymph Node in Colorectal Cancer

Lee JS, Lim JW, Choi SK, Chung EJ, Lee YJ, Hong SC, Kwon SI, Park ST, Ha WS

  • KMID: 2334278
  • J Korean Soc Coloproctol.
  • 2002 Oct;18(5):317-323.
PURPOSE: Metastasis of a colorectal carcinoma to regional lymph nodes indicates poor prognosis. The detection of lymph node metastasis is routinely performed by his topathological analysis of hematoxylin-eosin (H&E) stained...
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Detection of Epstein-barr virus by PCR and expression of LMP1, p53, CD44 in gastric cancer

Lee MA, Hong YS, Kang JH, Lee KS, Yoo JY, Lee KY

  • KMID: 2252838
  • Korean J Med.
  • 2002 Sep;63(3):261-266.
BACKGROUND: Epstein-Barr virus (EBV) is associated with various lymphoproliferative disorders and nasopharyngeal carcinoma. Recently some of the tumor cells of gastric cancer were observed to contain EBV sequence. We detected...
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The Histologic and Colonoscopic Features and p53 Protein Overexpression of Serrated Adenoma

Kim SG, Lee MS, Kim JO, Cheon GJ, Jung IS, Cheon YK, Cho JY, Lee JS, Jin SY, Shim CS

  • KMID: 2085017
  • Korean J Gastroenterol.
  • 2002 May;39(5):350-355.
BACKGROUND/AIMS: Serrated adenomas (SA) is a distinct form of colorectal neoplasia, in which adenomatous glands have a serrated epithelial arrangement observed in hyperplastic polyps. SA is defined as a neoplastic...
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The alteration of p16 protein in invasive cervical cancer

Ahn SN, Kim WG

  • KMID: 2262709
  • Korean J Obstet Gynecol.
  • 2002 Apr;45(4):602-609.
OBJECTIVE: Recently p16 gene has been found as a new factor for cervical carcinogenesis. The purpose of this study is to investigate the p16 protein alteration in invasive cervical cancers,...
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Expression of P-glycoprotein and p53 Protein in Stage IV Hepatocellular Carcinoma Treated with Systemic Chemotherapy

Cho SH, Cho HH, Kim YH, Chung J, Choi D, Cho K, Lee JH, Jeong SH, Han CJ, Kim YC, Lee JO, Chung JH, Lee SS

  • KMID: 2241234
  • Korean J Hepatol.
  • 2001 Dec;7(4):459-466.
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is a drug-resistant tumor. The expression of a multidrug resistant gene, P-glycoprotein (P-gp) is a major mechanism of drug resistance. The aims of our study were,...
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