Korean J Obstet Gynecol.  1997 Jan;40(1):123-128.

Comparison of Early and Mid-Second-Trimester Amniocentesis

• Ann HK
• Ryu HM
• Kim MY
• Kim ES
• Song HK
• Lee HK
• Han JR
• Kim JM
• Choi SK
• Han HW

Abstract

We sought to determine whether early amniocentesis is a safe and acceptable method of genetic evaluation in early pregnancy. During the 20-month period from February 1994 to September 1995, 80 consecutive early amniocentesis were performed transabdominally at 12(+3)-14(+6) weeks of gestation and 305 consecutive mid-second-trimester transabdominal amniocenteses were performed at 16(+0)-18(+0) weeks of gestation. All amniotic fluid samples were cultured using flask method. There were no significant differences between the early and mid-second-trimester amniocenteses in failed sampling, ambiguous results, pregnancy loss within 4 weeks after the procedure, pregnancy loss from 4 weeks after procedure to 28 weeks of gestation, preterm birth, and perinatal death. We may conclude that early amniocentesis is a safe and acceptable method for prenatal diagnosis.

Keyword

Early amniocentesis; Genetic evaluation

MeSH Terms

Amniocentesis*
Amniotic Fluid
Female
Pregnancy
Premature Birth
Prenatal Diagnosis