J Genet Med.  2012 Jun;9(1):22-24. 10.5734/JGM.2012.9.1.22.

Fetal Loss Rate after Mid-trimester Amniocentesis

• Han YJ
• Kim YY
• Lee SW
• Kim MH
• Chung JH
• Ahn HK
• Han JY
• Kim MY
• Yang JH
• Choi KH
• Park SY
• Ryu HM

• KMID: 2055565
• DOI: http://doi.org/10.5734/JGM.2012.9.1.22

Abstract

PURPOSE
The aim of this study was to asses the fetal loss rate after mid-trimester amniocentesis.
MATERIALS AND METHODS
This was a retrospective cohort study including singleton pregnant women who underwent mid-trimester amniocentesis at Cheil General Hospital from January 2008 through December 2010. The procedure-related fetal loss was defined as miscarriage within 2 weeks after amniocentesis. We evaluated the fetal loss rate within 2 weeks after amniocentesis and fetal loss rate before 24 gestational weeks.
RESULTS
During the study period, a total of 4,356 singleton pregnant women underwent mid-trimester amniocentesis. A total of Five hundred ninety six women were excluded owing to follow up loss and termination of pregnancy due to abnormal karyotype or major anomaly. At our institute, the fetal loss rate within 2 weeks was 0.1% and before 24 gestational weeks was 0.3% after amniocentesis.
CONCLUSION
The fetal loss rate after mid-trimester amniocentesis in our study is lower than previously reported rate. We suggest that amniocentesis is a safe procedure.

Keyword

Amniocentesis; Fetal loss rate

MeSH Terms

Abnormal Karyotype
Abortion, Spontaneous
Amniocentesis
Cohort Studies
Equidae
Female
Follow-Up Studies
Hospitals, General
Humans
Pregnancy
Pregnant Women
Retrospective Studies