Allergy Asthma Immunol Res.  2014 Jul;6(4):350-356. 10.4168/aair.2014.6.4.350.

Maternal Genetic Variants of IL4/IL13 Pathway Genes on IgE With "Western or Eastern Environments/Lifestyles"

• Zhang G
• Khoo SK
• Makela JM
• Candelaria P
• Hayden MC
• von Hertzen L
• Laatikainen T
• Vartiainen E
• Goldblatt
• Haahtela T
• LeSouef NP

• KMID: 2260216
• DOI: http://doi.org/10.4168/aair.2014.6.4.350

Abstract

PURPOSE
We investigated maternal genetic effects of four IL-4/IL-13 pathway genes as well as their interactions with the "Western or Eastern lifestyles/environments" on IgE in Karelian children.
METHODS
This study included 609 children and their mothers. Total IgE levels in children and mothers were measured and 10 single nucleotide polymorphisms (SNPs) in IL-4, IL-4Ra, IL-13, and STAT6 were genotyped in mothers and their children.
RESULTS
The maternal G allele of IL-13 130 (rs20541) was significantly (P=0.001) associated with decreased IgE in children in the Karelian population (Pooling Finnish and Russian children), as well as in Finnish (P=0.030) and Russian children (P=0.018). The IgE levels were significantly (P=0.001) higher in Russian children whose mothers were homozygous for the G allele of the IL-4Ra 50 (rs1805010) SNP than that in Russian children of mothers who were AG heterozygotes or AA homozygotes. After accounting for children's genotypes, we observed interactive effects on children's IgE for maternal IL-13 130 genotypes (P=0.014) and maternal IL-4Ra 50 genotypes (P=0.0003) with "Western or Eastern" lifestyles/environments. With the adjustment for multiple comparisons using a false discovery rate (FDR) of 0.05, the interactive effect of the maternal IL-4Ra50 SNP was significant.
CONCLUSION
Maternal genetic variants in IL-4/IL-13 pathway genes, such as IL-13 130 and IL-4Ra50, influenced IgE levels in school children that were independent of the children's genetic effects. These effects differ in "Western or Eastern" environments.

Keyword

Allergy; IgE; IL-4; IL-13; maternal genetic effects

MeSH Terms

Alleles
Child
Genotype
Heterozygote
Homozygote
Humans
Hypersensitivity
Immunoglobulin E*
Interleukin-13
Interleukin-4
Mothers
Polymorphism, Single Nucleotide
Immunoglobulin E
Interleukin-13
Interleukin-4

Figure

• 

  Fig. 1 Serum Total IgE in children and maternal genotypes of IL-13 130. (A) Karelian (Finnish+Russian), (B) Finnish, (C) Russian.

• 

  Fig. 2 Serum Total IgE in children and maternal genotypes of IL-4RA 50. (A) Karelian (Finnish+Russian), (B) Finnish, (C) Russian.

• 

  Fig. 3 The associations of maternal genotypes of IL-13 130 and IgE in children homozygous for the G allele of IL-13 130 (n=242). (A) Finnish, (B) Russian.

• 

  Fig. 4 The associations of maternal genotypes of IL-4RA 50 and IgE in children heterozygous AG of IL-4RA 50 (n=254). (A) Finnish, (B) Russian.

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