Korean J Med.
2011 Jun;80(Suppl 2):S278-S282.
A Case of Hemophagocytic Syndrome as a Complication of Acute Hepatitis A
- Affiliations
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- 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 2Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. dani@amc.seoul.kr
Abstract
- Virus-associated hemophagocytic syndrome (VAHS) is a severe hematological disease characterized by persistent fever, peripheral blood cytopenia, hyperferritinemia, hypertriglyceridemia, and hemophagocytosis in the bone marrow, spleen, or lymph nodes. Despite the high incidence of viral infections in the general population, VAHS complicated by hepatitis A infection is rare worldwide, and there is no standard treatment for VAHS. Treatments include correcting the peripheral blood cytopenia and controlling the infectious causes and immunosuppression, such as with cyclosporine A and corticosteroids. We report on a patient who was diagnosed with hepatitis A virus-associated VAHS, and has been free of signs and symptoms of VAHS for 2 years with a combination of corticosteroid and cyclosporin A.
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