Korean J Med.  2009 Aug;77(Suppl 1):S240-S244.

A case of adult-onset Still's disease combined with Sjogren's syndrome

• Jung YS
• Jung SY
• Lee KH
• Ha YJ
• Baek JH
• Park YB
• Lee SK

Abstract

Sjogren's syndrome is a chronic, slowly progressive autoimmune disease in which the exocrine glands are damaged by lymphocytic infiltration, resulting in xerostomia and xerophthalmia. Adult-onset Still's disease (AOSD) is a multi-systemic inflammatory disorder, characterized by a high spiking fever, an evanescent salmon-colored rash, arthralgia or arthritis, lymphadenopathy, leukocytosis, and the involvement of various organs. We report the case of a 59-year-old female patient with Sjogren's syndrome who presented with a fever of unknown origin. She was diagnosed with AOSD based on her high spiking fever, evanescent skin rash, arthralgia, lymphadenopathy, leukocytosis, sore throat, and hyperferritinemia after extensive investigations were performed to exclude other diseases. Her AOSD symptoms were successfully treated with high-dose glucocorticoid and methotrexate, without recurrence. We describe the case of a 59-year-old female patient with Sjogren's syndrome and AOSD.

Keyword

Sjogren's syndrome; Adult onset; Still's disease; Fever of unknown origin

MeSH Terms

Arthralgia
Arthritis
Autoimmune Diseases
Exanthema
Exocrine Glands
Female
Fever
Fever of Unknown Origin
Humans
Leukocytosis
Lymphatic Diseases
Methotrexate
Middle Aged
Pharyngitis
Recurrence
Sjogren's Syndrome
Still's Disease, Adult-Onset
Xerophthalmia
Xerostomia
Methotrexate