J Korean Soc Pediatr Endocrinol.  2007 Dec;12(2):150-154.

A Case of Sjogren's Syndrome with Hyperthyroidism

• Jung YH
• Choi IJ
• Jung JW

Abstract

Sjogren syndrome is a chronic, slowly progressive, autoimmune disease in which the exocrine glands are damaged by lymphocytic infiltration, resulting in xerostomia and xerophthalmia. Sjogren syndrome may occur in 2 forms: primary Sjogren syndrome, when the clinical manifestations of the syndrome are seen alone, and secondary Sjogren syndrome, when associated with another autoimmune disease, such as rheumatoid arthritis, systemic lupus erythromatosus, or scleroderma. Approximately one third of patients present with extraglandular manifestations: arthritis, Raynaud phenomenon, lymphadenopathy, lung involvement, vasculitis and peripheral nervous system involvement. About 10-50% of patients with Sjogren syndrome had evidence of thyroid disease, mainly hypothyroidism. Several inflammatory thyroid diseases are also considered to be autoimmune in origin. In this respect, the histologic picture of primary Sjogren syndrome exocrine glands and autoimmune thyroid glands show great similarities. Here, we report a new case of Sjogren syndrome accompanying with hyperthyroidism which affected a 10-year-old girl.

Keyword

Sjogren's syndrome; Hyperthyroidism

MeSH Terms

Arthritis
Arthritis, Rheumatoid
Autoimmune Diseases
Child
Exocrine Glands
Female
Humans
Hyperthyroidism*
Hypothyroidism
Lung
Lymphatic Diseases
Peripheral Nervous System
Raynaud Disease
Sjogren's Syndrome*
Thyroid Diseases
Thyroid Gland
Vasculitis
Xerophthalmia
Xerostomia