Korean J Nutr.  2005 Oct;38(8):656-662.

Effect of[6]-Gingerol on Inhibition of Cell Proliferation in MDA-MB-231 Human Breast Cancer Cells

Affiliations
  • 1Department of Food Science and Nutrition, Dankook University, Seoul, Korea. wkkim@dankook.ac.kr
  • 2Department of Sports Science, Seoul Sports Gracduate University, Seoul, Korea.

Abstract

Ginger (Zingiber officinale Roscoe, Zingiberaceae) is one of the most frequently and heavily consumed dietary condiments throughout the world. Besides its extensive use as a spice, the rhizome of ginger has also been used in traditional oriental herbal medicine for the management of symptoms such as common cold, digestive disorders, rheumatism, neurologia, colic, and motion-sickness. The oleoresin from rhizomes of ginger contains[6]-gingerol (1-[4'-hydroxy-3'-methoxyphenyl]-5-hydroxy-3-decanone) and its homologs as pungent ingredients that have been found to possess many interesting pharmacological and physiological activities, such as anti-inflammatory, analgesic, antipyretic, antiheatotoxic, and cardiotonic effects. However, the effect of[6]-gingerol on cell proliferation in breast cancer cell are not currently well known. Therefore, in this study, we examined effect of[6]-gingerol on protein and mRNA expression associated with cell proliferation in MDA-MB-231 human breast cancer cell lines. We cultured MDA-MB-231 cells in presence of 0, 2.5, 5 and 10 micrometer of[6]-gingerol.[6]-Gingerol inhibited breast cancer cell growth in a dose-depenent manner as determined by MTT assay. ErbB2 and ErbB3 protein and mRNA expression were decreased dose-dependently in cells treated with[6]-gingerol (p < 0.05). In addition, phosphorylated Akt levels and total Akt levels were markedly decreased in cells treated with 2.5 micrometer[6]-gingerol (p < 0.05). In conclusion, we have shown that[6]- gingerol inhibits cell proliferation through ErbB2 and ErbB3, reduction in MDA-MB-231 human breast cancer cell lines.

Keyword

[6]-gingerol; breast cancer cell; proliferation; EGFR; Akt

MeSH Terms

Breast Neoplasms*
Breast*
Cell Line
Cell Proliferation*
Colic
Common Cold
Condiments
Ginger
Herbal Medicine
Humans*
Rheumatic Diseases
Rhizome
RNA, Messenger
Spices
RNA, Messenger
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