Korean J Med.  2009 Nov;77(5):643-648.

A case of peripheral T-cell lymphoma with central nervous system and bilateral pulmonary involvement

• Koo TY
• Park BB
• Kim HY
• Kim WJ
• Choi JH
• Kim IS
• Lee YY

Abstract

Mature T-cell non-Hodgkin's lymphoma (NHL) has more frequent extranodal involvement and is less sensitive to chemotherapy than B-cell lymphoma. Peripheral T-cell lymphoma unspecified (PTCL-U) is rarely combined with pulmonary or CNS involvement. We report a case of PTCL-U with lung and CNS involvement that was treated with high-dose chemotherapy followed by autologous stem cell transplantation (ASCT). A 62-year-old man was admitted with right-side weakness and paresthesias, and was diagnosed with PTCL-U after alung biopsy. Successful complete remission was achieved after threecycles of IMEP (ifosfamide, methotrexate, etoposide, and prednisone) chemotherapywith concurrent intrathecal chemotherapy and subsequent high-dose chemotherapy with ASCT to treat potential advanced stage PTCL-U. The non-anthracycline-containing IMEP regimen can be effective for PTCL-U, especially in cases with CNS involvement.

Keyword

Peripheral T-cell lymphoma; Central nervous system and lung; IMEP; Stem cell transplantation

MeSH Terms

Biopsy
Central Nervous System
Etoposide
Humans
Lung
Lymphoma, B-Cell
Lymphoma, Non-Hodgkin
Lymphoma, T-Cell, Peripheral
Methotrexate
Middle Aged
Paresthesia
Stem Cell Transplantation
T-Lymphocytes
Etoposide
Methotrexate