Korean J Med.  2008 Jun;74(6):605-610.

Correlations between the prevalence of colonic neoplasia and Helicobacter pylori infection

• Hong EJ
• Park DI
• Sohn HJ
• Bae MH
• Kim HM
• Kim YS
• Byun SJ
• Park JH
• Kim HJ
• Cho YK
• Shon CI
• Jeon WK
• Kim BI

Abstract

BACKGROUND/AIMS: Helicobacter pylori infection is a recognized cause of chronic gastritis, peptic ulcer and gastric adenocarcinoma. However, both positive and negative associations with colorectal neoplasia have been reported. The aim of this study was to determine whether H. pylori infection is associated with an increased risk of colonic neoplasia in a Korean population.
METHODS
We examined 1,590 subjects (1,297 men and 293 women) who underwent colonoscopy and serologic testing for IgG antibodies against H. pylori at the Health promotion Center in Kangbuk Samsung Hospital and at Samsung Medical Center. We compared the prevalence of colonic neoplasia in the seropositive subjects with that of the seronegative subjects.
RESULTS
The overall prevalence of H. pylori in our study population was 56.2%. There were no significant differences of the baseline characteristics between the two groups. There was no statistically significant difference in the prevalence of colonic neoplasia between the seropositive group and the seronegative group (p=0.090).
CONCLUSIONS
These findings suggest that there is no significant association between H. pylori infection and colonic neoplasia.

Keyword

Helicobacter pylori; Colonic neoplasia

MeSH Terms

Adenocarcinoma
Antibodies
Colon
Colonoscopy
Gastritis
Health Promotion
Helicobacter
Helicobacter pylori
Humans
Immunoglobulin G
Male
Peptic Ulcer
Prevalence
Serologic Tests
Antibodies
Immunoglobulin G