Upper Gastrointestinal Lesions and Helicobacter pylori Infection in Patients with Colorectal Neoplasia

Kim, Hak Yang; Lee, Joon Ho; Kim, Jin Bong; Lee, Jin Heon; Kim, Yong Bum; Park, Choong Kee; Park, Chul Jae; Yoo, Jae Young

Abstract

BACKGROUND/AIMS: There are some reports which show higher Helicobacter pylori (H. pylori) seroprevalence in patients with colonic adenoma and carcinomas, than in control subjects. The H. pylori infection rate and simultaneous gastroduodenal lesions were evaluated to document the relationship between colonic lesions and H. pylori infection.
METHODS
Patients with colonic polyps or cancers who were confirmed by colonoscopic polypectomy or biopsy were studied. H. pylori infections were evaluated serologically and/or with CLO testing. Gastroduodenoscopy was performed.
RESULTS
Twenty six subjects were involved. The numbers of the patients with hyperplastic polyps, tubular adenomas and carcinomas were 7, 6 and 13, respectively. The H. pylori infection rate was 65.4%. Simultaneous gastroduodenal lesions were observed in 11 patients (42.3%) and H. pylori infections were found in 9 (81.8%). Among the 17 subjects with H. pylori infections, 9 subjects (52.9%) had simultaneous gastroduodenal lesions. In contrast, 2 subjects (22.2%) had upper gastrointestinal lesions among 9 subjects without H. pylori infections.
CONCLUSIONS
Patients with colorectal neoplasia can experience, simultaneous gastroduodenal lesions, especially in the cases involving H. pylori infection.