Korean J Med.  2008 Jul;75(1):88-92.

A case of lymphoplasmacytic sclerosing pancreatitis with pancreatic adenocarcinoma

• Choi YG
• Kim HJ
• Seok HS
• Kim S
• Chung WG
• Lee DY
• Chae SW

Abstract

Lymphoplasmacytic sclerosing pancreatitis (LPSP) is a rare entity that has been described under many different names; LPSP is an autoimmune form of chronic pancreatitis. LPSP may simulate a neoplastic process both clinically and radiologically. We report a case of LPSP with pancreatic adenocarcinoma. A 70-year-old woman was admitted to our hospital for evaluation of pancreatic duct dilatation. The CA 19-9 level was normal and the antinuclear antibody titer was negative. An abdominal CT revealed a low density nodule, 8 mm in size, in the body of the pancreas with parenchymal atrophy and mild dilatation of the main pancreatic duct in the body and tail portion. Endoscopic retrograde cholangiopancreaticography demonstrated a stricture of the main pancreatic duct in the body of the pancreas and mild dilatation of the upstream duct. She underwent subtotal pancreatectomy and splenectomy. The results of the pathologic examination of the resected tissue included pancreatic ductal adenocarcinoma with pancreatic intraepithelial neoplasia in the background of lymphoplasmacytic sclerosing pancreatitis.

Keyword

Lymphoplasmacytic sclerosing pancreatitis; Adenocarcinoma; Autoimmune pancreatitis

MeSH Terms

Adenocarcinoma
Aged
Antibodies, Antinuclear
Atrophy
Constriction, Pathologic
Dilatation
Female
Humans
Pancreas
Pancreatectomy
Pancreatic Ducts
Pancreatitis
Pancreatitis, Chronic
Splenectomy
Antibodies, Antinuclear