Korean J Nephrol.  2007 Mar;26(2):264-268.

A Case of Unilateral Renal Artery Stenosis with Contra-Lateral Focal Segmental Glomerulosclerosis in a Chronic Kidney Disease Patient

• Hong SJ
• Kim DK
• Ku CR
• Lee HS
• Choi KH
• Lee HY
• Han DS
• Jeong HJ
• Kim BS

Abstract

We report a case of focal segmental glomerulosclerosis (FSGS) with chronic renal failure in a patient with unilateral renal artery stenosis. A 38-year-old woman presented with malignant hypertension, massive proteinuria and renal insufficiency. MR angiography showed proximal stenosis of the right renal artery and biopsy of the left kidney revealed focal segmental glomerulosclerosis. The patient responded favorably to the angiotensin II receptor antagonist, as the blood pressure and urinary protein decreased. This case showed that FSGS is a pathophysiologic mechanism of renal injury in uncontrolled renovascular hypertension.

Keyword

Focal glomerulosclerosis; Malignant hypertension; Renal insufficiency; Renal artery obstruction

MeSH Terms

Adult
Angiography
Biopsy
Blood Pressure
Constriction, Pathologic
Female
Glomerulosclerosis, Focal Segmental*
Humans
Hypertension, Malignant
Hypertension, Renovascular
Kidney
Kidney Failure, Chronic
Proteinuria
Receptors, Angiotensin
Renal Artery Obstruction*
Renal Artery*
Renal Insufficiency
Renal Insufficiency, Chronic*
Receptors, Angiotensin