Korean J Nephrol.  2007 Mar;26(2):174-181.

The Impact of Serum Uric Acid Level on the Progression of IgA Nephropathy

• Chin HJ
• Na KY
• Cheong HI
• Kim YS
• Kim S
• Chae DW

Abstract

PURPOSE: Many evidences about hyperuricemia as a risk factor to hypertension and renal progression in kidney diseases have been reported. We have analyzed the impact of uric acid on renal progression of IgA nephropathy while getting rid of possible confounding variables and revealed the possible pathophysiology of uric acid in terms of hypertension or renal vasculopathy provoked by uric acid.
METHODS
We selected 172 patients with IgA nephropathy diagnosed by renal biopsy at Seoul National University Hospital. We adapted the criteria of renal progression as the final value of serum creatinine increased more then twice compared to the value at renal biopsy.
RESULTS
Serum uric acid was correlated with the severity of interstitial fibrosis and tubular atrophy and the presence of artherosclerosis. The incidence of hypertension during follow-up period was not different between low uric acid group and high uric acid group. The high uric acid level was an independent risk factor to renal progression in IgA nephropathy with multivariate analysis regardless of the presence of hypertension or artherosclerosis of renal pathologic finding. The high uric acid level was also a risk factor to renal progression in patients with estimated GFR more than 60 mL/min/1.73m2.
CONCLUSION
Serum uric acid was related to the presence of artherosclerosis and the renal progression of IgA nephropathy.

Keyword

Uric acid; Hypertension; IgA nephropathy

MeSH Terms

Atrophy
Biopsy
Confounding Factors (Epidemiology)
Creatinine
Fibrosis
Follow-Up Studies
Glomerulonephritis, IGA*
Humans
Hypertension
Hyperuricemia
Immunoglobulin A*
Incidence
Kidney Diseases
Multivariate Analysis
Risk Factors
Seoul
Uric Acid*
Creatinine
Immunoglobulin A
Uric Acid