Infusion-Related Toxicities of DMSO Containing Cryopreserved Blood

Kim, Byung Soo; Choi, In Kun; Kim, Suk Jin; Lim, Chae Seung; Seo, Jae Hong; Choi, Chul Won; Shin, Sang Won; Kim, Yeul Hong; Lee, Kap No; Kim, Jun Suk

Abstract

PURPOSE: We retrospectively evaluated infusion-related toxicities in the patients transfused with frozen-thawed blood mixed with dimethyl-sulfoxide (DMSO).
METHODS
The incidence and severity of infusion-related toxicities in the 25 patients transfused with frozen-thawed blood containing hematopoietic stem cells mixed with 10% DMSO were compaired with those of other 18 patients (11 patients;transfused with ABO-compatible allogeneic marrow blood without DMSO, 7 patients;transfused with platelet concentrates which were frozen with 6% DMSO and washed after thawing to remove DMSO). RESULT: The median transfusion volume of blood containing DMSO was 280cc and that of blood without DMSO was 180cc. The infusion-related toxicities of blood containing DMSO were nausea (96%, 24/25), febrile sensation (88%, 22/25), vomiting (48%, 12/25), hematuria (32%, 8/25), dyspnea (16%, 4/25), convulsion (8%, 2/25), and sudden death (4%, 1/25). That of blood without DMSO was febrile sensation (5.6%, 1/18). The incidence of infusion-related toxicities of blood containing DMSO was significantly higher than that of blood without DMSO (p<0.05).
CONCLUSION
It could be suggestive that the infusion-related toxicities of blood containing DMSO was occured more frequently and severely than those of blood without DMSO.