Korean J Blood Transfus.  1996 Dec;7(2):241-245.

Filtration Effects of Leukocyte Removal Filter for Platelet Concentrates

• Chi HS
• Kwon SW
• Oh WI
• Lee MK
• Park HJ
• Han TJ
• Choi BR
• Min TH

Abstract

Some variables can influence the efficiency of leukocyte removal filter for red cell concentrates. We performed this study to evaluate whether the filtration efficiency for platelet concentrates(PCs) can be influenced by bedside filter(PXL8K, Pall Corporation, USA) used, platelet storage time and transient stopping of platelet agitation, and to measure the amount of cytokines released from donor leukocytes in PCs during the storage time. In addition, we examined the effect of leukocyte reduction by filtration before the storage of PCs on the subsequent generation of cytokines. Any of the above mentioned variables did not make significant differences. From day 1 to day 5, there were significant increases in IL-1 beta (<1 vs. 8.6 pg/mL, p<0.05), IL-8 (<10 vs. 455.3 pg/mL, p<0.05) and TNF-alpha (<4 vs. 16.6 pg/mL, p<0.05) in unflltered PCs, whereas no increased revels of cytokines were found in the cases of prestorage filtration.

MeSH Terms

Blood Platelets*
Cytokines
Dihydroergotamine
Filtration*
Humans
Interleukin-1beta
Interleukin-8
Leukocytes*
Tissue Donors
Tumor Necrosis Factor-alpha
Cytokines
Dihydroergotamine
Interleukin-1beta
Interleukin-8
Tumor Necrosis Factor-alpha