Korean J Nephrol.  2008 Mar;27(2):238-242.

Multiple Myeloma Presented as Tubulointerstitial Nephritis

• Ryu DH
• Kim SM
• Park JW
• Do JY
• Yoon KW
• Cho HS
• Kim YJ

Abstract

Renal damage in patients with myeloma is one of the most important causes of acute renal failure. Although cast nephropathy characterized by cast formation in the distal nephron is the main renal lesion, a diverse spectrum of renal lesions can be observed in patients with myeloma. A 48-year-old woman was admitted to our hospital because of acute renal failure. The patient had been well until a few weeks earlier, when she experienced severe headaches. During the next week, she began to have general ache, became increasingly irritable, and began to have pain on both lower legs. After admission, her serum creatinine had increased up to 4.02 mg/dL, her anemia was more aggravated, and her 24 hour urine protein was 2.4 g. She had a monoclonal spike in her urine protein elctrophoresis. Her bone marrow was infiltrated by over 30% plasma cells, so she received hemodialysis and chemotherapy.

Keyword

Interstitial nephritis; Acute renal failure; Multiple myeloma

MeSH Terms

Acute Kidney Injury
Anemia
Bone Marrow
Creatinine
Female
Headache
Humans
Leg
Middle Aged
Multiple Myeloma
Nephritis, Interstitial
Nephrons
Plasma Cells
Renal Dialysis
Creatinine