Korean J Med.  2004 Dec;67(6):662-666.

A case of two consecutive deliveries in a woman with acromegaly

• Choi H
• Lee Y
• Chung IH
• Koh JH
• Kim MJ
• Shin YG
• Chung CH

Abstract

Acromegaly is a rare pituitary disorder and usually results from GH hypersecretion by a somatotroph adenoma. Disturbed pituitary function might lead to infertility or early pregnancy termination. Pregnancy in acromegaly is very rare. GH is a potent insulin antagonist, and pregnant patients with GH hypersecretion are prone to added glucose intolerance and diabetes. Pregnancy itself may impact the course of a pituitary tumor. In our case, pregnancy was uneventful and normal full-term infant was delivered at 1993 by vaginal delivery after transsphenoidal surgery and bromocriptine therapy. After delivery, GH and IGF-I level wasn't normalized. Postoperative pituitary MRI scan showed residual tumor. Therefore she received subsequent postoperative pituitary radiation (total dose : 5000 cGy). Next year, despite elevated GH and IGF-I, she delivered normal full-term infant. We report a case of two consecutive deliveries in a woman with acromegaly despite elevated GH and IGF-I levels after transsphenoidal surgery and radiation therapy.

Keyword

Acromegaly; Pregnancy; Growth Hormone

MeSH Terms

Acromegaly*
Bromocriptine
Female
Glucose Intolerance
Growth Hormone
Growth Hormone-Secreting Pituitary Adenoma
Humans
Infant
Infertility
Insulin
Insulin-Like Growth Factor I
Magnetic Resonance Imaging
Neoplasm, Residual
Pituitary Diseases
Pituitary Neoplasms
Pregnancy
Bromocriptine
Growth Hormone
Insulin
Insulin-Like Growth Factor I