Korean J Hematol.  2009 Mar;44(1):28-35. 10.5045/kjh.2009.44.1.28.

The Effectiveness of High Dose Dexamethasone for the Initial Treatment of Childhood Acute Idiopathic Thrombocytopenic Purpura

• Choi JS
• Huh JK
• You CW

• KMID: 2252170
• DOI: http://doi.org/10.5045/kjh.2009.44.1.28

Abstract

BACKGROUND
Corticosteroids and intravenous immunoglobulin (IV-Ig) have been used asfirst line treatments for acute idiopathic thrombocytopenic purpura (AITP) in children. High dose dexamethasone (HD) has been reported to be effective for chronic refractory ITP and for the initial treatment of AITP in adults. There has been no report about HD as the initial treatment for childhood AITP. We assessed the effectiveness of HD for the initial treatment of childhood AITP, as compared to IV-Ig.
METHODS
25 Patients with newly diagnosed AITP were enrolled. We conducted a prospective, randomized study to compare the two treatment options. 11 patients were treated with IV-Ig and 14 patients were treated with HD. The platelet counts were assessed at 3, 5, 7, 14 and 21 days after the beginning of the treatment. The adverse effects were noted, and the patients were followed for more than 6 months.
RESULTS
Both the IV-Ig and HD groups showed a rapid rise of the platelet counts and the platelet counts were maintained at 3, 5, 7, 14 and 21 days. The difference of platelet counts between the two groups was significant at day 5 (P<0.05). During the follow-up period, 5 patients had a recurrence: 2 in IV-Ig group and 3 in HD group. All 5 patients were re-treated with HD and they had a good response. One of the recurred patients in the IV-Ig group had chronic ITP. Some side effects were observed, but they were not severe enough to necessitate the discontinuation of treatment.
CONCLUSION
We conclude that HD is as effective and safe as high dose IV-Ig for the initial treatment of childhood AITP. The choice between these treatment options can be made according to the cost-effectiveness and the therapy-related risks.

Keyword

Idiopathic thrombocytopenic purpura; Immunoglobulin; Dexamethasone

MeSH Terms

Adrenal Cortex Hormones
Adult
Child
Dexamethasone
Follow-Up Studies
Humans
Immunoglobulins
Platelet Count
Prospective Studies
Purpura, Thrombocytopenic, Idiopathic
Adrenal Cortex Hormones
Dexamethasone
Immunoglobulins

Figure

• 

  Fig. 1. The effectiveness of HD compares to IV-Ig. Bars represent mean±SD (P＜0.05).

Reference

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