Korean J Med.  1997 Aug;53(2):250-255.

Two Cases of Invasive Aspergillosis Following Orthotopic Heart Transplantation

• Yoon JH
• Lee SG
• Ko KW
• Hong SK
• Hyon MS
• Kim MA
• Park SH
• Park GY
• Kim HJ
• Oh MH

Abstract

Case 1: A 39-year-old man underwent orthotopic heart transplantation on November 1994 for dilated cardiomyopathy. His postoperative course was unevenful and medications included daily cyclosporin A, Immuran and prednisone. On December 13.1994, he developed cough and sore throat. Chest radiographs revealed multiple patch growing lesions. Sputum fungus culture revealed Aspergillus Fumigatus. The patient was treated with daily infusion of amphotericin B. He remains well without evidence of relapse of Aspergillus, Case 2: This 39-year-old man had undergone orthotopic heart transplantation on November 16 1994 for dilated cardiomyopathy. In December 7.1994. he developed recurrent syncope. Chest radiographs revealed fungus ball like lesion on right lung field. On open lung biopsy and wedge resection of the mass was performed. Aspergillosis and CMV infection was demonstrated in the biopsy specimen. The patient was treated with conventional amphotericin B therapy for over 7weeks and Ganciclovir for over 2weeks. At the end of therapy chest X-ray showed only small residual scar in the area of previous mass.

Keyword

Heart transplantation; Invasive aspergillosis

MeSH Terms

Adult
Amphotericin B
Aspergillosis*
Aspergillus
Aspergillus fumigatus
Azathioprine
Biopsy
Cardiomyopathy, Dilated
Cicatrix
Cough
Cyclosporine
Fungi
Ganciclovir
Heart Transplantation*
Heart*
Humans
Lung
Pharyngitis
Prednisone
Radiography, Thoracic
Recurrence
Sputum
Syncope
Thorax
Amphotericin B
Azathioprine
Cyclosporine
Ganciclovir
Prednisone