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Development of Aspergillus fumigatus-induced chronic atopic dermatitis mouse model

Park A, Park H, Yu J

PURPOSE: Atopic dermatitis (AD) is the most common chronic and relapsing inflammatory skin disease with skin barrier defects and altered immune responses. Chronic inflammation leads to irreversible fibrosis in the...
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Fungal Allergen Propensity Study Confirmed Through Multiple Allergosorbent Chemiluminescent Assay

Choi Y, Park J

BACKGROUND: Exposure and sensitization to fungal allergens can evoke the development and worsen allergic diseases. Many patients with allergies show multiple positive reactions to different allergens. OBJECTIVE: The purpose of this...
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Aspergillus fumigatus infection in an ostrich with an enlarged neck due to respiratory problems

This study describes a sudden death in an ostrich (Struthio camelus) with a big neck. Grossly, the air sacs were thickened. Yellow to white, round or coalescent material was scattered...
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Effect of Temperature and Relative Humidity on Growth of Aspergillus and Penicillium spp. and Biocontrol Activity of Pseudomonas protegens AS15 against Aflatoxigenic Aspergillus flavus in Stored Rice Grains

Mannaa M, Kim KD

In this study, we evaluated the effect of different temperatures (10, 20, 30, and 40 °C) and relative humidities (RHs; 12, 44, 76, and 98%) on populations of predominant grain fungi...
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Allergic bronchopulmonary mycosis – pathophysiology, histology, diagnosis, and treatment

Asano K, Kamei K, Hebisawa A

Allergic bronchopulmonary mycosis (ABPM) develops mainly in patients with asthma or cystic fibrosis via types I and III hypersensitivity reactions to filamentous fungi. Aspergillus spp., especially Aspergillus fumigatus, is the...
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Biocontrol Activity of Volatile-Producing Bacillus megaterium and Pseudomonas protegens Against Aspergillus and Penicillium spp. Predominant in Stored Rice Grains: Study II

Mannaa M, Kim KD

In our previous studies, Bacillus megaterium KU143, Microbacterium testaceum KU313, and Pseudomonas protegens AS15 have been shown to be antagonistic to Aspergillus flavus in stored rice grains. In this study,...
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A Case of Fungal Ball Causing Acute Dacryocystitis

Hwang YS, Yang HJ, Paik JS, Yang SW

PURPOSE: We report a case of fungal ball after Endoscopic Dacryocystorhinostomy (DCR) in a 40-year-old female patient. CASE SUMMARY: A 40-year-old female patient was admitted to our hospital for left lower...
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Sputum Inflammatory Mediators Are Increased in Aspergillus fumigatus Culture-Positive Asthmatics

Ghebre MA, Desai D, Singapuri , Woods J, Rapley L, Cohen S, Herath A, Wardlaw AJ, Pashley CH, May R, Brightling CE

Aspergillus fumigatus sensitization and culture in asthma are associated with disease severity and lung function impairment, but their relationship with airway inflammation is poorly understood. We investigated the profile of...
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Drosophila melanogaster as a Model for Studying Aspergillus fumigatus

AL-Maliki , Martinez S, Piszczatowski P, Bennett JW

Drosophila melanogaster is a useful model organism that offers essential insights into developmental and cellular processes shared with humans, which has been adapted for large scale analysis of medically important...
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Frequency and effect of type 1 hypersensitivity in patients from India with chronic obstructive pulmonary disease and associated upper airways symptoms

Kumar A, Kunal S, Shah A

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is now recognized as a systemic disorder with many comorbidities. Atopy in patients with COPD and upper airways symptoms has not been characterized. OBJECTIVE: We...
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Assessment of the Cytotoxic and Apoptotic Effects of Chaetominine in a Human Leukemia Cell Line

Yao J, Jiao R, Liu C, Zhang Y, Yu W, Lu Y, Tan R

Chaetominine is a quinazoline alkaloid originating from the endophytic fungus Aspergillus fumigatus CY018. In this study, we showed evidence that chaetominine has cytotoxic and apoptotic effects on human leukemia K562...
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The Mycobiota of Air Inside and Outside the Meju Fermentation Room and the Origin of Meju Fungi

Kim DH, Kim SH, Kwon SW, Lee JK, Hong SB

The fungi on Meju are known to play an important role as degrader of macromolecule of soybeans. In order to elucidate the origin of fungi on traditional Meju, mycobiota of...
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The Zinc Transport Systems and Their Regulation in Pathogenic Fungi

Jung WH

Zinc is an essential micronutrient required for many enzymes that play essential roles in a cell. It was estimated that approximately 3% of the total cellular proteins are required for...
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In Vitro Antifungal Activity and Mode of Action of 2',4'-Dihydroxychalcone against Aspergillus fumigatus

Seo YH, Kim SS, Shin KS

2',4'-Dihydroxychalcone (2',4'-DHC) was identified from a heat shock protein 90 (Hsp90)-targeting library as a compound with Hsp90 inhibitory and antifungal effects. In the presence of 2',4'-DHC (8 microg/mL), radial growth...
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Case of seropositive allergic bronchopulmonary aspergillosis in a 10-year-old girl without previously documented asthma

Shin JE, Shim JW, Kim DS, Jung HL, Park MS, Shim JY

Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease due to bronchial colonization of Aspergillus fumigatus that occurs in susceptible patients with asthma or cystic fibrosis. A 10-year-old girl was...
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Allergic Bronchopulmonary Aspergillosis Presenting as Recurrent Mass-like Consolidation

Choe YH

Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitive disease showing various radiographic and clinical manifestations. Its clinical course has not been fully understood. Here I describe a case of a 23-year-old...
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Delayed Diagnosis of Small Cell Lung Cancer in a Patient with Allergic Bronchopulmonary Aspergillosis

Jung WS, Jang JW, Park SY, Choe YH, Lee YC, Kim SR

Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity disorder induced by Aspergillus fumigatus that occurs generally in patients with underlying chronic airway disorders. However, the development of ABPA associated with lung...
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Seasonal Variation in Skin Sensitivity to Aeroallergens

Choi IS, Lee SS, Myeong E, Lee JW, Kim WJ, Jin J

PURPOSE: We previously demonstrated seasonal variation in sensitization to aeroallergens in a small group of patients with exercise-induced asthma. This study was performed to confirm the relationship in a much...
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Expression and Activity of Catalases Is Differentially Affected by GpaA (Ga) and FlbA (Regulator of G Protein Signaling) in Aspergillus fumigatus

Shin KS, Yu JH

Vegetative growth signaling of the opportunistic human pathogenic fungus Aspergillus fumigatus is mediated by GpaA (Galpha). FlbA is a regulator of G protein signaling, which attenuates GpaA-mediated growth signaling in...
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A Case of Acute Cerebral Aspergillosis Complicating Influenza A/H1N1pdm 2009

Kim MJ, Kim MK, Kang CK, Jun KI, Bang JH, Park SW, Oh MD

Invasive aspergillosis is a rare complication in patients with influenza infection. Several cases of invasive pulmonary aspergillosis accompanying influenza infections were reported during the influenza A/H1N1pdm 2009. We encountered a...
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