Korean J Dermatol.  2008 May;46(5):710-714.

Two Cases of Primary Cutaneous Marginal Zone B-cell Lymphoma

• Lee KY
• Han EC
• Kim DY
• Chung KY

Abstract

Primary cutaneous marginal zone B-cell lymphoma, known as the cutaneous counterpart of mucosa-associated lymphatic tissue lymphoma (MALT lymphoma), is the most frequent of the primary cutaneous B-cell lymphoma. It is one of the low-grade lymphomas of B-cell type, which has an excellent prognosis with indolent behavior, despite frequent cutaneous recurrences. Histologically, cutaneous marginal zone B-cell lymphoma is composed of polymorphous infiltrate that includes centrocyte-like, centroblast-like, monocytoid, and lymphoplasmacytoid lymphocytes. We present two cases of primary cutaneous marginal zone B-cell lymphoma. A 48-year-old woman visited the dermatologic clinic with 1.5x1.5 cm sized, skin colored, palpable nodule on the left temporal area and a 26-year-old man visited the dermatologic clinic with 1x1 cm sized erythematous nodule on the nose. Both of them showed compatible histologic findings of marginal zone B-cell lymphoma and had no past medical history and no evidence of metastasis on PET-CT and bone marrow biopsy. The woman was treated with radiation treatment after excision and the man was treated with radiation treatment alone. Follow-up indicates that 1 year after treatment there is no evidence of recurrence.

Keyword

MALT lymphoma; Marginal zone B-cell lymphoma

MeSH Terms

Adult
B-Lymphocytes
Biopsy
Bone Marrow
Female
Follow-Up Studies
Humans
Lymphocytes
Lymphoid Tissue
Lymphoma
Lymphoma, B-Cell
Lymphoma, B-Cell, Marginal Zone
Lymphoma, Non-Hodgkin
Middle Aged
Neoplasm Metastasis
Nose
Prognosis
Recurrence
Skin