Korean J Dermatol.  2008 May;46(5):648-651.

A Case of Leukocytoclastic Vasculitis after Use of Sorafenib (Nexavar(R))

• Kim HJ
• Kim JH
• Kim JB
• Kim HK
• Ko YS
• Joh OJ
• Lee JS
• Song KY

Abstract

Sorafenib (Nexavar(R)) is an oral multikinase inhibitor that was recently approved for use in metastatic renal cancer. It is currently undergoing investigation for the treatment of locally advanced renal cancer and in other tumor types. It has a broad spectrum of activity in treating multiple tyrosine kinases, including angiogenic factors VEGFR and PDGFR. Common cutaneous toxicities experienced with sorafenib include facial and scalp erythema, hand-foot syndrome, splinter hemorrhages, and alopecia. We report a case of a 57 year-old man diagnosed as renal cell carcinoma with distant metastaisis, who developed a leukocytoclastic vasculitis on the extremities after use of sorafenib.

Keyword

Leukocytoclastic vasculitis; Nexavar(R); Sorafenib

MeSH Terms

Alopecia
Angiogenesis Inducing Agents
Carcinoma, Renal Cell
Erythema
Extremities
Hand-Foot Syndrome
Hemorrhage
Kidney Neoplasms
Niacinamide
Phenylurea Compounds
Phosphotransferases
Scalp
Tyrosine
Vasculitis
Vasculitis, Leukocytoclastic, Cutaneous
Angiogenesis Inducing Agents
Niacinamide
Phenylurea Compounds
Phosphotransferases
Tyrosine
Vasculitis, Leukocytoclastic, Cutaneous