Korean J Gynecol Oncol Colposc.  2004 Jun;15(2):149-153.

A Case of Sertoli-Leydig Cell Tumor of the Ovary

• Lee KW
• Park SW
• Shin KS
• Kim MS
• Ku SY
• Kwak TR

Abstract

The Sertoli-Leydig cell tumor is a rare sex cord-stromal tumor of the ovary, accounting for less than 0.5% of all primary ovarian neoplasm. They occur predominantly in the second and third decades, rarely before puberty or after the menopause. The most common symptom is menstrual disorder including vaginal bleeding and occasionally masculinization is accompanied with this symptom. This symptom is the results of excessive testosterone production of Leydig cell, but approximately 50% of patients with Sertoli-Leydig cell tumor have no endocrine manifestations. The majority of these tumors are benign and almost all are localized unilaterally. Prognosis proves generally favorable with 5-year survival rate of 70~90%. Recurrence is rare. We have experienced a case of intermediately differentiated Sertoli-Leydig cell tumor accompanied with multiple uterine leiomyomas in a 30 years old woman who had oligomenorrhea, hirsutism and infertility. We report this case with a brief review of literature.

Keyword

Sertoli-Leydig cell tumor; Oligomenorrhea; Hirsutism; Infertility

MeSH Terms

Adolescent
Adult
Female
Hirsutism
Humans
Infertility
Leiomyoma
Menopause
Oligomenorrhea
Ovarian Neoplasms
Ovary*
Prognosis
Puberty
Recurrence
Sertoli-Leydig Cell Tumor*
Sex Cord-Gonadal Stromal Tumors
Survival Rate
Testosterone
Uterine Hemorrhage
Testosterone