Korean J Hepatobiliary Pancreat Surg.  1999 Aug;3(2):223-227.

A Case of Duodenal Adenosquamous Carcinoma

• Lee M
• Shim IB
• Koh JS
• Chung JH
• Choi DW

Abstract

Adenosquamous carcinoma in the duodenum is extremely rare disease entity and only 6 cases were reported all over the world so far. Recently we encountered a 62 year-old female patient with duodenal adenosquamous carcinoma. The patient subsequently underwent Whipple's operation. Histopathologic examination revealed two pathologic components composed of adenocarcinoma and squamous cell carcinoma. The metastatic foci of lymph nodes were composed of pure squamous cell carcinoma. For differential diagnosis, we performed several special stains including high molecular weight cytokeratin(HMWCK), low molecular weight cytokeratin(LMWCK), carcinoembryogenic antigen( CEA), mucicarmine, periodic acid-Schiff(PAS). Immunohistochemical stains demonstrated LMWCK, CEA, mucicarmine positivity for glandular component and HMWCK for squamous component. Weak positivity for squamous component was observed with PAS stain. The pathogenesis of adenosquamous carcinoma is controversial issue and not resolved yet, so we discussed the histogenesis of adenosquamous carcinoma.

Keyword

Duodenum; Adenosquamous carcinoma

MeSH Terms

Adenocarcinoma
Carcinoma, Adenosquamous*
Carcinoma, Squamous Cell
Coloring Agents
Diagnosis, Differential
Duodenum
Female
Humans
Lymph Nodes
Middle Aged
Molecular Weight
Rare Diseases
Coloring Agents