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The mixture effect of propyl paraben and bisphenol A on the uterotrophic response in the ovariectomized rats after oral administration

Park J, Lee H, Choi DW, Park K

Recent studies reported bisphenol A (BPA) and propyl paraben (PrP) are found in human urine, blood, and breast milk samples as well as in food, packaging, socks, and clothes. This...
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The Rescue on Reperfusion Damage in Cerebral Infarction by Nelonemdaz (RODIN) Trial: Protocol for a Double-Blinded Clinical Trial of Nelonemdaz in Patients with Hyperacute Ischemic Stroke and Endovascular Thrombectomy

Lee JS, Lee JS, Gwag BJ, Choi DW, An CS, Kang HG, Song TJ, Ahn SH, Kim CH, Shin DI, Kwon SU

Background and Purpose Nelonemdaz (Neu2000) has both selective antagonism against 2B subunit of N-methyl-D-aspartate receptor and antioxidant activity. This drug provides sufficient evidence of neuroprotection in acute cerebral ischemia/reperfusion models....
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Metabolite Changes during the Transition from Hyperthyroidism to Euthyroidism in Patients with Graves’ Disease

Lee HY, Sim BC, Nga HT, Moon JS, Tian J, Linh NT, Ju SH, Choi DW, Setoyama D, Yi HS

Background: An excess of thyroid hormones in Graves’ disease (GD) has profound effects on systemic energy metabolism that are currently partially understood. In this study, we aimed to provide a...
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Toll‐Like Receptor 7 (TLR7) Mediated Transcriptomic Changes on Human Mast Cells

Cho KA, Choi DW, Park M, Kim YH, Woo SY

Background: Mast cells are skin immune sentinels located in the upper dermis, where wheal formation and sensory nerve stimulation take place. Skin inflammation is occasionally accompanied by mast cell-driven responses...
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The impact of portal vein resection on outcome of hilar cholangiocarcinoma

Kim KB, Choi DW, Heo JS, Han IW, Shin SH, You Y, Park DJ

Backgrounds/Aims: Portal vein resection (PVR) with major hepatic resection can increase the rate of curative resection for hilar cholangiocarcinoma (HC). However, the oncologic role and safety of PVR is still...
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Interaction Effects between Individual Socioeconomic Status and Regional Deprivation on Onset of Diabetes Complication and Diabetes-Related Hospitalization among Type 2 Diabetes Patients: National Health Insurance Cohort Sample Data from 2002 to 2013

Jang J, Ju YJ, Lee DW, Lee SA, Oh SS, Choi DW, Lee HJ, Shin J

Background: In this study, we aimed to investigate the interaction effects of individual socioeconomic status and regional deprivation on the onset of diabetes complications and diabetes-related hospitalization among type 2...
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A comprehensive study of deaths due to exposure to humidifier disinfectant in Korea: focusing on medical records, assessment of exposure to humidifier disinfectants, and causes of death

Ju YJ, Lee S, Sheen S, Choi DW, Leem JH, Lee SY

OBJECTIVES: We aimed to determine the characteristics of the deceased victims of deaths caused by exposure to humidifier disinfectants, and present the distribution of the victims’ data submitted for damage...
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Clinical outcomes of pancreaticoduodenectomy for pancreatic ductal adenocarcinoma depending on preservation or resection of pylorus

Kim YJ, Shin SH, Han IW, Ryu Y, Kim N, Choi DW, Heo JS

Backgrounds/Aims: The comparative effectiveness of pylorus-resecting pancreaticoduodenectomy (PRPD) and pylorus-preserving pancreaticoduodenectomy (PPPD) in pancreatic head cancer is still disputed. The aim of this study was to analyze the data obtained...
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Subtype of intraductal papillary mucinous neoplasm of the pancreas is important to the development of metachronous high-risk lesions after pancreatectomy

Kwon JE, Jang KT, Ryu Y, Kim N, Shin SH, Heo JS, Choi DW, Han IW

BACKGROUNDS/AIMS: Although intraductal papillary mucinous neoplasm (IPMN) has showed a favorable prognosis compared to pancreatic ductal adenocarcinoma, its recurrence patterns have somewhat questionable in detail. After partial pancreatectomy for IPMN,...
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Long-term clinical outcomes after endovascular management of ruptured pseudoaneurysm in patients undergoing pancreaticoduodenectomy

You Y, Choi SH, Choi DW, Heo JS, Han IW, Han S, Shin SW, Park KB, Park HS, Cho SK, Han SH

PURPOSE: Recent studies have analyzed the short-term clinical outcomes of ndovascular management. However, the long-term outcomes are unknown. This study aimed to investigate clinical outcomes after endovascular management for ruptured...
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Catastrophic Health Expenditure and Trend of South Korea in 2017

Kim Y, Choi DW, Park EC

Catastrophic health expenditure refers to spending more than a certain level of household's income on healthcare expenditure. The aim of this study was to investigate the proportion of households that...
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Splenic vessel patency: is it real menace to perform laparoscopic splenic vessel-preserving distal pancreatectomy

Park DJ, Han IW, Han SH, Han SJ, You YH, Rhu YJ, Heo JS, Choi SH, Choi DW

PURPOSE: This study compared the patency of the splenic vessels between laparoscopic and open spleen and splenic vessel-preserving distal pancreatectomy. METHODS: We retrospectively reviewed a database of 137 patients who underwent...
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Clinical significance of revised microscopic positive resection margin status in ductal adenocarcinoma of pancreatic head

You Y, Choi DW, Heo JS, Han IW, Choi SH, Jang KT, Han S, Han SH

PURPOSE: Recent studies have suggested microscopic positive resection margin should be revised according to the presence of tumor cells within 1mm of the margin surface in resected specimens of pancreatic...
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The Association between Social Contacts and Depressive Symptoms among Elderly Koreans

Yang J, Park EC, Lee SA, Lee JE, Choi DW, Chae W, Jang SI

OBJECTIVE: South Korea has an increasing aging population; thus, the management of depressive symptoms in elderly individuals is important. In this population, fewer social contacts might be a risk factor...
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Surgical Strategy for T2 Gallbladder Cancer: Nationwide Multicenter Survey in Korea

Lee SE, Kim SW, Han HS, Lee WJ, Yoon DS, Cho BH, Choi IS, Kim HJ, Hong SC, Lee SM, Choi DW, Park SJ, Kim HJ, Jang JY, Korean Pancreas Surgery Club

BACKGROUND: Although all guidelines suggest that T2 gallbladder (GB) cancer should be treated by extended cholecystectomy (ECx), high-level scientific evidence is lacking because there has been no randomized controlled trial...
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Catastrophic Health Expenditure and Trend of South Korea in 2016

Choi DW, Kim W, Park EC

Catastrophic health expenditure refers to when a household spends more than 40 percent of disposable income for out-of-pocketexpenses for healthcare. This study investigates the percentage of South Korean household which...
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Prognostic factors of non-functioning pancreatic neuroendocrine tumor revisited: The value of WHO 2010 classification

Bu J, Youn S, Kwon W, Jang KT, Han S, Han S, You Y, Heo JS, Choi SH, Choi DW

BACKGROUNDS/AIMS: Various factors have been reported as prognostic factors of non-functional pancreatic neuroendocrine tumors (NF-pNETs). There remains some controversy as to the factors which might actually serve to successfully prognosticate...
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Highlights of the Third Expert Forum of Asia-Pacific Laparoscopic Hepatectomy; Endoscopic and Laparoscopic Surgeons of Asia (ELSA) Visionary Summit 2017

Park JI, Kim KH, Kim HJ, Cherqui D, Soubrane O, Kooby D, Palanivelu C, Chan A, You YK, Wu YM, Chen KH, Honda G, Chen XP, Tang CN, Kim JH, Koh YS, Yoon YI, Cheng KC, Duy Long T, Choi GH, Otsuka Y, Cheung TT, Hibi T, Kim DS, Wang HJ, Kaneko H, Yoon DS, Hatano E, Choi IS, Choi DW, Huang MT, Kim SG, Lee SG

The application of laparoscopy for liver surgery is rapidly increasing and the past few years have demonstrated a shift in paradigm with a trend towards more extended and complex resections....
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JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells

Choi DW, Kim DK, Kanai Y, Wempe MF, Endou H, Kim JK

Most normal cells express L-type amino acid transporter 2 (LAT2). However, L-type amino acid transporter 1 (LAT1) is highly expressed in many tumor cells and presumed to support their increased...
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Portal Vein Stenting for Delayed Jejunal Varix Bleeding Associated with Portal Venous Occlusion after Hepatobiliary and Pancreatic Surgery

Hyun D, Park KB, Cho SK, Park HS, Shin SW, Choo SW, Do YS, Choo IW, Choi DW

OBJECTIVE: The study aimed to describe portal stenting for postoperative portal occlusion with delayed (≥ 3 months) variceal bleeding in the afferent jejunal loop. MATERIALS AND METHODS: Eleven consecutive patients (age...
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