Korean J Hepatobiliary Pancreat Surg.  2008 Jun;12(2):134-139.

Biological Markers for Making the Differential Diagnosis between Intraductal Papillary Mucinous Tumor and Mucinous Cystic Tumor of the Pancreas

• Jang JY
• Lee SE
• Hwang DW
• Kim WH
• Ahn YJ
• Yoon YS
• Han HS
• Kim SW

Abstract

PURPOSE: Although intraductal papillary mucinous tumor (IPMT) and mucionus cystic tumor (MCT) share many common features, they are 2 clinically different disease entities. The aims of this study were to compare the clinicopathological characteristics of IPMT and MCT and to find molecular markers for making the differential diagnosis between IPMT and MCT
METHODS
Forty-one patients with IPMT and 29 MCT patients who all underwent resection between 1994 and 2003 were enrolled in this study. After one gastrointestinal pathologist reviewed the pathological slides, we compared the clinico-pathological features of the two diseases. Immunohistochemical staining with using 17 biological markers was performed to find useful molecular markers for making the differential diagnosis.
RESULTS
Besides the clinical features like gender, the tumor size and location, the patient's age and the radiological images, we found differences of the expressions of PR(p<0.001), ER(p<0.001), MUC2(p=0.038) and MUC5A(p=0.001) between IPMT and MCT.
CONCLUSION
PR, ER, MUC2 and MUC5A can be useful in making the final differential diagnosis between IPMT and MCT. Considering the different gene expressions, further studies are needed to clarify the different pathogenesis of these two diseases entities.

Keyword

intraductal papillary mucinous neoplasm; mucinous cystic neoplasm; ER; PR; MUC

MeSH Terms

Biomarkers
Diagnosis, Differential
Gene Expression
Humans
Mucins
Pancreas
Mucins