Korean J Gastrointest Endosc.
2002 Apr;24(4):225-229.
A Case of Adult Type Colonic Hypoganglionosis
- Affiliations
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- 1Department of Internal Medicine, Daegu Catholic University, College of Medicine and Catholic Medical Center, Daegu, Korea. Kwonjg@cuth.cataegu.ac.kr
- 2Department of Surgery, Daegu Catholic University, College of Medicine and Catholic Medical Center, Daegu, Korea.
- 3Department of Pathology, Daegu Catholic University, College of Medicine and Catholic Medical Center,Daegu, Korea.
- 4Department of Internal Medicine, Fatima Hospital, Daegu, Korea.
Abstract
- Hypoganglionosis is a rare form of intestinal neuronal malformation, which is characterized by scarce ganglia and a reduced number of parasympathetic nerves in the intestinal wall. The pathogenesis of intestinal neuronal malformation is mainly attributed to developmental disorders of the enteric nervous system (ENS). Furthermore, the ENS can be damaged during the postnatal period by ischemic, inflammatory, autoimmunological process or neurotoxic agents. Subsequently abnormalties of the ENS may cause chronic constipation or ileus. Intestinal neuronal malformation should be suspected in patients with a history of chronic stool retention and appropriate radiographic findings. Hypoganglionosis is extremely difficult to establish the diagnosis histochemically unless full-thickness biopsies are performed. Recently we experienced a case of adult type hypoganglionosis, which is assumed to be an acquired type. It was treated with right hemicolectomy.
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