Korean J Anesthesiol.
2008 Nov;55(5):527-537. 10.4097/kjae.2008.55.5.527.
Pharmacogenetics of anesthetics
- Affiliations
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- 1Department of Anesthesiology and Pain Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. kyemin@paik.ac.kr
- KMID: 2242989
- DOI: http://doi.org/10.4097/kjae.2008.55.5.527
Abstract
- Genetic and/or environmental factors lead to large inter-individual variability in the efficacy and the side effects of drugs. Pharmacogenetics is the study of genetically determined differences in drug response. It focuses on the genetic variations involved in drug metabolism, transporters and receptors, which result in the pharmacokinetic and pharmacodynamic differences. Recently, pharmacogenetic studies on anesthetics and analgesics have been carried out actively. The pharmacogenetics of the commonly used drugs in anesthetic practice is reviewed.
