Korean J Biol Psychiatry.  2021 Apr;28(1):1-6. 10.22857/kjbp.2021.28.1.001.

Current Pharmacogenetics in Psychiatry

Affiliations
  • 1Department of Psychiatry, Hanyang University Guri Hospital, Guri, Korea
  • 2Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea
  • 3Department of Psychiatry, Yong-In Mental Hospital, Yongin, Korea

Abstract

Pharmacogenetics is opening a new era of precision medicine in psychiatry. Drug-metabolizing enzymes are characterized by genetic polymorphisms, which render a large portion of variability in individual drug metabolism. Dose adjustment based on pharmacogenetics knowledge is a first step to translate pharmacogenetics into clinical practice. However, diverse factors including cost-effectiveness should be addressed to provide clinical recommendation. To address current challenges in pharmacogenetics testing in psychiatry, this review provides an update regarding genotyping (SNP analysis, array, and next-generation sequencing), genotype-phenotype correlations, and cost-effectiveness. The current updates on pharmacogenetics in psychiatry will provide guidance for both clinician and researchers to have a consensus in harmonizing efforts to advance the pharmacogenetics field in a part of precision medicine in psychiatry.

Keyword

Pharmacogenetics; Drug-metabolizing enzyme; CYP450; Genotyping; Psychiatry
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