Korean J Anesthesiol.  1996 Mar;30(3):300-304. 10.4097/kjae.1996.30.3.300.

The Hemodynamic Changes Induced by Doses of Propofol

• Kim KS
• Jeon MS
• Suh JK
• Yoo HK
• Chon SU

• KMID: 2240405
• DOI: http://doi.org/10.4097/kjae.1996.30.3.300

Abstract

BACKGROUND: Propofol(2,6 diisopropylphenol) is a potent hypnotic currently formulated as an oil-in-water emulsion. Although previous studies reported decreases in arterial pressures and heart rate, no detailed studies of hemodynamic effects of propofol administration alone are available in Korea. This study is to determine the hemodynamic changes induced by doses of propofol.
METHODS
Sixty patients(ASA physical status 1 or 2) were divided randomly into three groups as follows: group I, pmpofol 1.5 mg/kg; group 2, propofol 2.0 mg/kg; group 3, propofol 2.5 mg/kg. Heart rate and mean arterial pressure were measured by Datascope 2200I, and cardiac index(CI) and systemic vascular resistance index(SVRI) were obtained by doppler cardiac output monitor(Datascope Accucom 2) at the suprasternal notch before and after induction of propofol.
RESULTS
Statistically significant decreases in mean arterial pressure were observed since 2 min after induction. CI was decreased from 2.94+/-0.51 to 2.35+/-0.57 L/min/m(2) at 6 min after induction of propofol 2.5 mg/kg, and no differences among groups. CI was also decreased in group 1 and 2 but without any significance. SVRI was decreased in all groups but there were no significance, and no differences among groups.
CONCLUSIONS
The data suggest that the usual doses of propofol do not significantly cause hemodynamic changes, and a decrease in mean arterial pressure is a result of decreased CI and reduced SVRI.

Keyword

Anesthetics; intravenous; propofol; Measurement techniques; hemodynamics

MeSH Terms

Anesthetics
Arterial Pressure
Cardiac Output
Heart Rate
Hemodynamics*
Korea
Propofol*
Vascular Resistance
Anesthetics
Propofol