Korean J Anesthesiol.  1996 Oct;31(4):484-493. 10.4097/kjae.1996.31.4.484.

The Effect of Thiopental on Jugular Venous Oxygen Saturation during Rewarming in Cardiopulmonary Bypass

• Hwang KS
• Choi IC
• Cho MW

• KMID: 2240359
• DOI: http://doi.org/10.4097/kjae.1996.31.4.484

Abstract

BACKGROUND: We examined the ability of thiopental known to have protective effect on brain to prevent brain damage resulting from cerebral ischemia due to global imbalance in cerebral metabolic rate for oxygen and cerebral blood flow during rewarming period in cardiopulmonary bypass.
METHODS
Jugular venous oxygen saturation(SjO2) was used as a reflection of cerebral oxygen balance. Thiopental 20 mg/kg(thiopental 10 mg/kg bolus and 10 mg/kg continuous infusion) was received during rewarming from hypothermic cardiopulmonary bypass of 27~30.5degrees C to 36degrees C and SjO2 compared with control group.
RESULTS
In 8 patients of the 25 control group(32%) and 7 patients of the 24 thiopental group(29.2%), SjO2 were < or =50% with no difference between groups. Artery-jugular vein oxygen content differences (C(a-j)O2) and O2 extraction ratios increased significantly in SjO2 < or =50% patients suggesting increased oxygen consumption. Awake time prolonged significantly with thiopental.
CONCLUSIONS
Thiopental(20 mg/kg) administration during rewarming in cardiopulmonary bypass for cerebral protection is not recommended.

Keyword

Anesthetics; intravenous; thiopental; Brain; protection; Heart; cardiopulmonary bypass; Monitoring; blood gas; venous

MeSH Terms

Anesthetics
Brain
Brain Ischemia
Cardiopulmonary Bypass*
Heart
Humans
Oxygen Consumption
Oxygen*
Rewarming*
Thiopental*
Veins
Anesthetics
Oxygen
Thiopental