Korean J Anesthesiol.  1987 Aug;20(4):516-520. 10.4097/kjae.1987.20.4.516.

The Effects of Dantrolene Sodium in Prevention of Malignant Hyperthermia

• Yeom SS
• Lee KN
• Lee CH
• Moon JI

• KMID: 2239522
• DOI: http://doi.org/10.4097/kjae.1987.20.4.516

Abstract

Malignant hyperthermia is defined as a potentially fatal hypermetabolic syndrome char-acteriged by hyperpyrexia, muscle rigidity, tachycardia, respiratory and metabolic acidosis. cyanosis etc. It ia susceptible in patients with musculoskeletal diaease such as strabismus, kyphosco-liosia, hernia, cleft palate, cryptorchidism, but there is no single diagnostic method to detect a susceptible patient. Fortunately s-CPK is elevated in 70% of carriers, so we checked a-CPK and a-LDH bel- ore operation in patients scheduled for correction of congenital strabismus and classified into group 1 (norirlal a-CPK group) and group 2 (elevated s-CPK group) . We administered Oantrolene sodium to group 2 before operation and compared the changes of s-CPK and s-LDH after operation. The results are as fallows, 1) s-CPK was lowered after administration of Dantrolene sodium in group 2 . (from 76.4 IU/L to 48.5IU/L) 2) s-CPK elevation after operation was much less in group 2 than group 1. (56.1+/-58.7 IU/L vs 164.7+/-127.1 IU/L) In conclusion, it would seem that Dantrelene aodium was affective in prevention of mali-gnant hyperthermia.

MeSH Terms

Acidosis
Cleft Palate
Cryptorchidism
Cyanosis
Dantrolene*
Fever
Hernia
Humans
Male
Malignant Hyperthermia*
Muscle Rigidity
Sodium
Strabismus
Tachycardia
Dantrolene
Sodium