Korean J Anesthesiol.  1994 Jan;27(1):29-34. 10.4097/kjae.1994.27.1.29.

Effects of Propofol or Thiopental on the Intracranial Pressure in the Patients for Transsphenoidal Approach

• Shin YS
• Jang JH
• Lee KY
• Chung SS

• KMID: 2239231
• DOI: http://doi.org/10.4097/kjae.1994.27.1.29

Abstract

The effects of propofol and thiopental on the intracranial pressure (ICP) were investigated in forty, male or female adult patients with transsphenoidal approach for pituitary tumors. A 7-French epidural catheter was inserted into the lumbar subarachnoid space and connected to a pressure transducer for the monitoring of ICP and the air or saline injection. And then, the inhalation anesthesia with 3%-isoflurane via mask following thiopental and metocurine was done. The mean ICPs at the preanesthetic period, 10 min after 3%-isoflurane inhalation with mask, immediately after intubation and after 5-10 ml air or saline injection were about 4, 8, 12, 16 and 30 mmHg, respectively. With the equipotent hypnotic dose of propofol (1 mg/kg)(Group I) or thipental (2 mg/kg)(Group II), the increased ICPs were diminished to the level prior to air or saline injection. Even if mean arterial pressure (MAP) with either agents were reduced significantly comparing with pre-administration values, cerebral perfusion pressure (CPP) were significantly decreased only with group I. The authors conclude that propofol could be ascertained to reduce the increased ICP as thiopental did, but propofol reduced MAP to higher degree than thiopental. Accordingly, CPP were lower with propofol than with thiopental.

Keyword

Intracranial pressure; Propofol; Thiopental; Transsphenoidal approach

MeSH Terms

Adult
Anesthesia, Inhalation
Arterial Pressure
Catheters
Female
Humans
Inhalation
Intracranial Pressure*
Intubation
Male
Masks
Perfusion
Pituitary Neoplasms
Propofol*
Subarachnoid Space
Thiopental*
Transducers, Pressure
Propofol
Thiopental