Korean J Anesthesiol.
2009 Aug;57(2):221-224. 10.4097/kjae.2009.57.2.221.
Acute liver injury after sevoflurane anesthesia: A case report
- Affiliations
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- 1Department of Anesthesiology and Pain Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. hyunkyolim@yonsei.ac.kr
- 2Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea.
- KMID: 2238094
- DOI: http://doi.org/10.4097/kjae.2009.57.2.221
Abstract
- Halothane, isoflurane and desflurane are metabolized to hepatotoxic trifluoroacetyl proteins. But sevoflurane is metabolized to hexafluoroisopropanol. Hexafluoroisopropanol has a low binding affinity for liver protein and is therefore rapidly converted to glucuronidate that are excreted in the urine. Thus sevoflurane has been considered to have a very low potential for hepatotoxicity. We report a case of a 67 years old woman who developed acute hepatic dysfunction after sevoflurane anesthesia.
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