Korean J Anesthesiol.  2006 Sep;51(3):359-362. 10.4097/kjae.2006.51.3.359.

A Case of Postoperative Acute Hepatic Dysfunction after Sevoflurane Anesthesia: A case report

• Son Y
• Cheong YK
• Kim DJ

• KMID: 2237438
• DOI: http://doi.org/10.4097/kjae.2006.51.3.359

Abstract

We report a case of a suspected acute hepatic dysfunction after general anesthesia with sevoflurane. A 71 year old female underwent a laparoscopic appendectomy under O2-N2O-sevoflurane anesthesia. She had no history of anesthesia, allergy, hypertension, diabetes or hepatitis. Four hours after surgery, she developed a conscious disturbance and became comatose. There was a marked increase in the serum aspartate aminotransferase, alanine aminotransferase, activated partial thromboplastin time and prothrombin time level, but the platelet and eosinophil counts were within the normal range. Her hepatic dysfunction improved after conservative therapy. She recovered gradually and was discharged after 24 days of hospitalization. Sevoflurane is believed to be the possible cause of the acute hepatic dysfunction in this case.

Keyword

hepatic dysfunction; hepatic enzyme; sevoflurane

MeSH Terms

Aged
Alanine Transaminase
Anesthesia*
Anesthesia, General
Appendectomy
Aspartate Aminotransferases
Blood Platelets
Coma
Eosinophils
Female
Hepatitis
Hospitalization
Humans
Hypersensitivity
Hypertension
Partial Thromboplastin Time
Prothrombin Time
Reference Values
Alanine Transaminase
Aspartate Aminotransferases