Korean J Anesthesiol.  1996 Aug;31(2):232-238. 10.4097/kjae.1996.31.2.232.

The Analgesic Efficacy of Transdermal Fentanyl Patch with Intravenous Ketorolac by Patient Controlled Analgesia after Total Abdominal Hysterectomy

• Kim DH
• Min HR
• Park NH

• KMID: 2237788
• DOI: http://doi.org/10.4097/kjae.1996.31.2.232

Abstract

BACKGROUND: The analgesic efficacy and safety of transdermal fentanyl patch(TDFP) combined with intravenous ketorolac administration were evaluated.
METHODS
TDFP releasing 75 mcg/h (Group 1) or 50 mcg/h (Group 2) or placebo (Group 3) were applied to 60 women at 2 hours before abdominal gynecologic surgery. Postoperatively, patients self-administered intravenous ketorolac as required using patient controlled analgesia. Each group was assessed following 48 hours with respect to vital signs, VAS pain score, satisfaction score, side effects, and cumulative ketorolac use.
RESULTS
After operation, pain score and ketorolac demand were significantly lower and satisfaction score and side effects were significantly higher in TDFP group (Group 1, 2) than control group (Group 3).
CONCLUSIONS
If TDFP is applied 2 hour before surgery, combined with a bolus dose of 200 mcg i.v. fentanyl at induction of anesthesia and ketorolac i.v. infusion in the postoperative period, it provides a significant degree of background analgesia without respiratory depression.

Keyword

Analgesia patient-controlled; postoperative; transdermal delivery; Analgesics fentanyl; intravenous; Pain postoperative

MeSH Terms

Analgesia
Analgesia, Patient-Controlled*
Anesthesia
Female
Fentanyl*
Gynecologic Surgical Procedures
Humans
Hysterectomy*
Ketorolac*
Postoperative Period
Respiratory Insufficiency
Vital Signs
Fentanyl
Ketorolac