Korean J Anesthesiol.
1996 Aug;31(2):195-201. 10.4097/kjae.1996.31.2.195.
Effects of Lidocaine, Fentanyl, and Esmolol on Blood Pressure and Heart Rate Changes owing to Endotracheal Intubation during Propofol Induction
- Affiliations
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- 1Department of Anesthesiology, College of Medicine, Ewha Womans University, Seoul, Korea.
- KMID: 2237783
- DOI: http://doi.org/10.4097/kjae.1996.31.2.195
Abstract
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BACKGROUND: Laryngoscopy and endotracheal intubation for general anesthesia cause tachycardia and hypertension due to sympathetic stimulation. The purpose of this study is comparison of effects of lidocaine, fentanyl, and esmolol on blood pressure and heart rate changes owing to tracheal intubation during propofol induction.
METHODS
Pateints were randomly received one of the following study drug intravenously prior to induction : Group 1(normal saline 5 ml, n=20) ; Group 2 (lidocaine 1.5 mg/kg, n=20) ; Group 3 (fentanyl 2 microgram/kg, n=20) ; Group 4 (esmolol 1.0 mg/kg, n=20). Anesthesia was induced with propofol 2.5 mg/kg IV and then maintained with 50% nitrous oxide in oxygen and 1.0 vol% isoflurane. Systolic and diastolic blood pressure and heart rate were measured preinduction, after induction, immediately after intubation, and 1, 3, 5, 7, 9, 11 minutes following intubation.
RESULTS
After intubation, the increase in systolic blood pressure and heart rate were blunted significantly compared with the control group in the group 3 (p<0.05). In the group 4, the increase in blood pressure was not suppressed but modified and tachycardia was not prevented after intubation.
CONCLUSIONS
Fentanyl 2 microgram/kg was suppressed blood pressure changes and effective in attenuating tachycardia during propofol induction compare with control and lidocaine groups. Esmolol 1.0mg/kg was effective in attenuating blood pressure changes owing to tracheal intubation.
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