Korean J Anesthesiol.  1997 Jun;32(6):924-930. 10.4097/kjae.1997.32.6.924.

Propofol Does not Prevent to Increase Intraocular Pressure During Tracheal Intubation

• Kim SY
• Huh NS
• Park DP
• Cha SC

• KMID: 2237754
• DOI: http://doi.org/10.4097/kjae.1997.32.6.924

Abstract

BACKGROUND
Anesthesiologists should understand the physiology of intraocular pressure and the implications of anesthetic drugs and maneuvers on intraocular pressure(IOP). Although most anesthetics reduce IOP, succinylcholine causes a transient but significant increase in IOP. And thiopental by itself does not prevent to increase blood pressure, IOP. This study was designed to evaluate the preventive effect of propofol on IOP changes during tracheal intubation.
METHODS
IOP was measured with a hand-held applanation tonometer in the eye. Baseline(control) IOP was measured before the induction of anesthesia(stage 1) and serial measurements of IOP were made after administration of the induction agent before intubation(stage 2), immediately after intubation(stage 3) and 10 minutes after intubation(stage 4). Heart rate and systolic blood pressure were recorded simultaneously. According to induction agent and neuromuscular blocker, the 60 patients were divided into control group(C; thiopental, succinylcholine), pretreatment group(T) using defasciculation dose of vecuronium bromide, propofol group(P; propofol, succinylcholine) and vecuronium group(V; propofol, vecuronium bromide).
RESULTS
Administration of either propofol or thiopenal resulted in a significant reduction in IOP(P<0.01). At stage 2, IOP of gpoup P and V were significantly lower than that of group C(P<0.05). At stage 3, IOP increased significantly compared to the values of stage 1 in all group(P<0.01). At stage 4, IOP decreased significantly compared to the values of stage 1 in all group(P<0.01), but there was no significant difference between groups in IOP at stage 4.
CONCLUSIONS
Propofol may be a useful induction agent of general anesthesia for opthalmic surgery, but cannot prevent to increase IOP during endotracheal intubation.

Keyword

Anesthetics; intravenous; propofol; Monitoring; intraocular pressure

MeSH Terms

Anesthesia, General
Anesthetics
Blood Pressure
Heart Rate
Humans
Intraocular Pressure*
Intubation*
Intubation, Intratracheal
Neuromuscular Blockade
Physiology
Propofol*
Succinylcholine
Thiopental
Vecuronium Bromide
Anesthetics
Propofol
Succinylcholine
Thiopental
Vecuronium Bromide