Korean J Anesthesiol.  2006 Sep;51(3):330-334. 10.4097/kjae.2006.51.3.330.

Median Effective Concentration (EC(50)) of Propofol for Insertion of Laryngeal Mask Airway and Laryngeal Tube in Children

• Park HJ
• Yoon TG
• Kim CS
• Kim SD
• Kim HS

• KMID: 2237433
• DOI: http://doi.org/10.4097/kjae.2006.51.3.330

Abstract

BACKGROUND: The median effective concentration, EC(50), for the supraglottic airway (predicted plasma concentration equilibrated with the effect site at which supraglottic airway insertion is successful in 50% of patients) of propofol in children was not known. The aim of this study was to determine the EC(50) with a target-controlled infusion of propofol to insert a classic laryngeal mask airway (LMA) and laryngeal tube (LT) in pediatric patients.
METHODS
Pediatric patients scheduled for urologic, orthopedic, or plastic surgery lasting less than 2 hr under general anesthesia were enrolled in this study. The patients were divided into two groups in a randomized, double blind manner. After applying a standard cardiorespiratory monitor, anesthesia was carried out with a target-controlled infusion (TCI) using the stelpump program. The initial target concentration of propofol was 5microgram/ml, and in accordance with Dixon's up-and-down, the propofol concentration for consecutive patients in each group was varied with increments or decrements of 0.2microgram/ml based on the previous patient insertion result.
RESULTS
The EC(50) of propofol required to insert a LMA and LT was 5.5+/-0.2microgram/ml and 5.6+/-0.2microgram/ml, respectively.
CONCLUSIONS
The EC50 of propofol is similar for LMA and LT.

Keyword

anesthesia intravenous; child; laryngeal mask airway; propofol

MeSH Terms

Anesthesia
Anesthesia, General
Child*
Humans
Laryngeal Masks*
Orthopedics
Plasma
Propofol*
Surgery, Plastic
Propofol