Korean J Anesthesiol.  2003 Jan;44(1):18-23. 10.4097/kjae.2003.44.1.18.

The Target Plasma Concentration of Propofol Required to Insert a Laryngeal Mask Airway without Muscle Relaxant Use

• Yeom JH
• Cho SY

• KMID: 1860677
• DOI: http://doi.org/10.4097/kjae.2003.44.1.18

Abstract

BACKGROUND: We evaluated laryngeal mask airway (LMA) insertion conditions, hemodynamic changes and bispectral index (BIS) responses during the induction of anesthesia with target controlled infusion (TCI) of propofol.
METHODS
Ninety patients (ASA 1 or 2, 18-64 years) were allocated randomly to receive an infusion to achieve and maintain target blood concentration of a 4, 5 and 6micro gram/ml. LMA was inserted after loss of consciousness. LMA insertion conditions, hemodynamic and BIS responses were evaluated.
RESULTS
Loss of consciousness and LMA insertion were more rapid in patients with propofol target blood concentration of a 6micro gram/ml than at the other concentrations. Also, full attenuation of larygeal reflexes on the first try was greater in the 6micro gram/ml group than the other groups.
CONCLUSIONS
We conclude that propofol administration at a target blood concentration of 6micro gram/ml allow successful insertion of LMA without major hemodynamic changes.

Keyword

Bispectral index; laryngeal mask airway; propofol; target-controlled infusion

MeSH Terms

Anesthesia
Hemodynamics
Humans
Laryngeal Masks*
Plasma*
Propofol*
Reflex
Unconsciousness
Propofol