Korean J Anesthesiol.  2000 Mar;38(3):409-419. 10.4097/kjae.2000.38.3.409.

The Effect of Epidural Anesthesia on Coagulation Following Vascular Surgery in Patients with Arteriosclerosis Obliterance

• Choi YJ
• Kim JM
• Kim AR

• KMID: 2237278
• DOI: http://doi.org/10.4097/kjae.2000.38.3.409

Abstract

BACKGROUND: The purpose of this study was to examine the relationship of epidural anesthesia with coagulation status and surgery outcome following lower extremity revascularization.
METHODS
Twenty patients with arteriosclerosis obliterance (ASO) scheduled for lower extremity vascular reconstruction were randomized to receive either general anesthesia or combined general-epidural anesthesia. An additional 20 randomly selected patients without atherosclerotic vascular disease undergoing lower abdominal or lower extremity surgery served as controls for coagulation status. In the group with general anesthesia, anesthesia was induced by administration of pentothal sodium and succinylcholine and maintained with N2O-O2, isoflurane and vecuronium. In the group with combined anesthesia, epidural anesthesia was performed at the level of L2-3 or L3-4 epidural space using 2% lidocaine, followed by general anesthesia same as general group. Postoperative pain control was followed by on-demand oral or intravenous narcotics in the general group and followed by epidural 0.125% bupivacaine and morphine in the combined group. The coagulation status was monitored using thrombelastography (TEG) and standard coagulation tests.
RESULTS
The ASO patients were hypercoagulable compared to the control patients before operation and on the first postoperative day. The hypercoagulability was attenuated postoperatively in the combined group. In the ASO-general group, postoperative MA, alpha and TEG index were 69.5 +/- 6.1 mm, 53.3 +/- 7.5 degree and 1.18 1.29 respectively, but in the ASO-combined anesthesia group, they were 58.0 +/- 6.2 mm, 38.0 +/- 4.0 degree and - 0.38 +/- 1.20 respectively (P < 0.05). The rates of postoperative complications did not significantly differ between the two groups.
CONCLUSIONS
In patients with arteriosclerosis obliterance undergoing arterial reconstructive surgery, thrombelastographic evidence of increased platelet-fibrinogen interaction is associated with early postoperative thrombotic events, and epidural anesthesia is associated with beneficial effects on coagulation status.

Keyword

Anesthesia: general; combined general-epidural; Measurement techniques: standard coagulation tests; thromboelastography; Monitoring: coagulation; Surgery: vascular

MeSH Terms

Anesthesia
Anesthesia, Epidural*
Anesthesia, General
Arteriosclerosis*
Bupivacaine
Epidural Space
Humans
Isoflurane
Lidocaine
Lower Extremity
Morphine
Narcotics
Pain, Postoperative
Postoperative Complications
Sodium
Succinylcholine
Thiopental
Thrombelastography
Thrombophilia
Vascular Diseases
Vecuronium Bromide
Bupivacaine
Isoflurane
Lidocaine
Morphine
Narcotics
Sodium
Succinylcholine
Thiopental
Vecuronium Bromide