Korean J Anesthesiol.  2003 Nov;45(5):617-621. 10.4097/kjae.2003.45.5.617.

Perioperative Coagulation Responses to Heparin and Dextran Following Arterial Bypass in Patients with Arteriosclerosis Obliterans

• Rhee KY

• KMID: 1935951
• DOI: http://doi.org/10.4097/kjae.2003.45.5.617

Abstract

BACKGROUND: The administration of low dose heparin and dextran therapy in patients with arterial bypass surgery is thought to prevent thrombosis and graft occlusion. The purpose of this study was to evaluate the effectiveness of low dose heparin and dextran in atherosclerosis patients presenting hypercoagulability.
METHODS
Whole blood coagulation was evaluated using thrombelastography and standard coagulation testing before and a day after surgery in nine atherosclerotic patients and nine control patients. Heparin 5000 U and dextran 500 ml were administrated in atherosclerotic patients during their operations.
RESULTS
Atherosclerotic patients showed higher maximal amplitude compared to the control patients during preoperative thrombelastography. After surgery atherosclerotic patients revealed no significant change, but the control group became more hypercoagulable in status compared to the preoperative period.
CONCLUSIONS
Intravenous heparin and dextran prevented postoperative change to a more hypercoagulable state than the preoperative status in atherosclerotic patients undergoing arterial bypass surgery.

Keyword

ASO (arteriosclerosis obliterans); anticoagulants; heparin; dextran; TEG (thrombelastography)

MeSH Terms

Anticoagulants
Arteriosclerosis Obliterans*
Arteriosclerosis*
Atherosclerosis
Blood Coagulation
Dextrans*
Heparin*
Humans
Preoperative Period
Thrombelastography
Thrombophilia
Thrombosis
Transplants
Anticoagulants
Dextrans
Heparin