Korean J Anesthesiol.  1997 Sep;33(3):463-466. 10.4097/kjae.1997.33.3.463.

Activated Coagulation Time (ACT) Differences between Arterial and Venous Blood Samples in Patients with Open Heart Surgery

• Ham BM
• Kim YL
• Lee SC
• Lee JH
• Kim MH
• Jo DH

• KMID: 2091158
• DOI: http://doi.org/10.4097/kjae.1997.33.3.463

Abstract

BACKGROUND: Activated coagulation time (ACT) is commonly used to guide heparin and protamine dosing during cardiovascular surgery. There are many factors that influence the ACT such as time of test, hemodilution, temperature, aprotinin and etc. We considered the other factor that influence the ACT, the route of blood sample.
METHODS
This study included 40 patients who were scheduled for cardiac surgery. Whole blood was sampled through arterial and central venous line at 10 minutes after surgical incision and heparin administration. The ACT was measured with Hemochron 801 blood coagulation timer with 12 mg of celite surface activator.
RESULTS
At 10 minutes after surgical incision and heparin administration, arterial blood and venous blood ACTs were 127 20, 537 214 seconds and 118 18, 496 145 seconds respectively (p<0.05).
CONCLUSIONS
We conclude that the venous blood ACT is more less than arterial blood ACT during cardiovascular surgery.

Keyword

Blood, arterial blood, coagulation, heparin, venous blood; Monitoring, activated coagulation time

MeSH Terms

Aprotinin
Blood Coagulation
Diatomaceous Earth
Heart*
Hemodilution
Heparin
Humans
Thoracic Surgery*
Aprotinin
Diatomaceous Earth
Heparin