Korean J Anesthesiol.  2014 Jan;66(1):23-27. 10.4097/kjae.2014.66.1.23.

Effect of pretreatment with palonosetron on withdrawal movement associated with rocuronium injection

• Cho K
• Lee SH
• Lee W
• Chu BK
• Kim MH
• Lim SH
• Lee KM

• KMID: 2237239
• DOI: http://doi.org/10.4097/kjae.2014.66.1.23

Abstract

BACKGROUND
The main disadvantage of rocuronium is the pain associated with vascular injection. We evaluated the efficacy of palonosetron for reducing pain after rocuronium injection.
METHODS
Eighty patients scheduled for elective surgery were randomly divided into two groups: Group C (normal saline 1.5 ml, n = 40) and Group P (palonosetron 0.075 mg, n = 40). Anesthesia was induced with thiopental 5 mg/kg and the test drug was injected over 10 seconds. Thirty seconds after the injection of the test drug, rocuronium 0.6 mg/kg was injected over 30 seconds and the response was recorded. Injection pain was graded using a 4-point scale. The grade was 0 points for no movement, 1 point for wrist movement, 2 points for elbow or shoulder movement, and 3 points for whole body movement. Mean arterial pressure and heart rate were recorded on arrival in the operating room and before and 30 seconds after rocuronim injection.
RESULTS
There was no significant difference in the grade 1 response between the two groups; however, the grade 2 and 3 responses in Group P were 5 (12.5%) and 4 (10%), respectively, which were significantly lower than in Group C, with 13 (32.5%) responses for each grade. There were no significant differences in hemodynamic changes within each group. However, the difference in mean arterial pressure before and after the injection of rocuronium was significantly larger in Group C compared to Group P.
CONCLUSIONS
Pretreatment with palonosetron 0.075 mg reduced the incidence and severity of withdrawal movement after rocuronium administration.

Keyword

Injections; Pain; Palonosetron; Rocuronium

MeSH Terms

Anesthesia
Arterial Pressure
Elbow
Heart Rate
Hemodynamics
Humans
Incidence
Operating Rooms
Shoulder
Thiopental
Wrist
Thiopental