Korean J Anesthesiol.  2010 Jul;59(1):13-16. 10.4097/kjae.2010.59.1.13.

Effect of pretreatment with acetaminophen on withdrawal movements associated with injection of rocuronium: a prospective, randomized, double-blind, placebo controlled study

• Jeon Y
• Baek SU
• Park SS
• Kim SO
• Baek WY
• Yeo JS

• KMID: 2236481
• DOI: http://doi.org/10.4097/kjae.2010.59.1.13

Abstract

BACKGROUND
Withdrawal movement during rocuronium injection is a common, unresolved adverse effect. We aimed to investigate the effect of IV acetaminophen pretreatment on withdrawal movement during rocuronium injection.
METHODS
This study enrolled 120 American Society of Anesthesiologists (ASA) I-II patients undergoing general anesthesia. They were randomly assigned to three treatment groups. After occluding venous drainage using a tourniquet on the upper arm, the saline group received 5 ml of 0.9% sodium chloride solution, the lidocaine group received 40 mg of lidocaine, and the acetaminophen group received 50 mg of acetaminophen. During injection of pretreatment drug, pain was assessed on a four-point scale. The tourniquet was released after 120 seconds and anesthesia was performed using thiopental sodium 5 mg/kg followed by rocuronium 0.6 mg/kg. The withdrawal movement was graded on a four-point scale in a double-blind manner.
RESULTS
The incidence of pain on pretreatment injection in saline, lidocaine, and acetaminophen groups was 7.7%, 5.1%, and 2.5%, respectively. The incidence of withdrawal movements was 77.5% in saline group, 32.5% in lidocaine group, and 37.5% in acetaminophen group (P < 0.05).
CONCLUSIONS
Acetaminophen and lidocaine reduced the incidence of withdrawal movement after rocuronium injection compared with saline.

Keyword

Acetaminophen; Injection; Lidocaine; Rocuronium; Withdrawal movement

MeSH Terms

Acetaminophen
Androstanols
Anesthesia
Anesthesia, General
Arm
Drainage
Humans
Incidence
Lidocaine
Prospective Studies
Sodium Chloride
Thiopental
Tourniquets
Acetaminophen
Androstanols
Lidocaine
Sodium Chloride
Thiopental