Korean J Anesthesiol.  2011 Dec;61(6):465-469. 10.4097/kjae.2011.61.6.465.

Dilution and slow injection reduces the incidence of rocuronium-induced withdrawal movements in children

• Shin YH
• Kim CS
• Lee JH
• Sim WS
• Ko JS
• Cho HS
• Jeong HY
• Lee HW
• Kim SH

• KMID: 1854058
• DOI: http://doi.org/10.4097/kjae.2011.61.6.465

Abstract

BACKGROUND
The aim of this study was to evaluate whether slow injection of diluted rocuronium could reduce rocuronium-induced withdrawal movements effectively in children.
METHODS
After loss of consciousness, rocuronium 0.6 mg/kg was administered into 171 children according to the pre-assigned groups as follows: Group CF, injection of non-diluted rocuronium over 5 seconds; Group CS, injection of non-diluted rocuronium over 1 minute; Group DF, injection of diluted rocuronium (10 times) over 5 seconds; Group DS, injection of diluted rocuronium over 1 minute. An investigator who was blind to the injection techniques recorded patient movements followed by rocuronium injection.
RESULTS
The incidence of withdrawal movement in Group CF was highest among the groups (all P < 0.0001). Moreover, withdrawal movement was less frequently observed in Group DS than in Groups CS and DF (P = 0.021 and P = 0.007, respectively).
CONCLUSIONS
Slow injection of diluted rocuronium reduced the incidence of withdrawal movements in children.

Keyword

Child; Injections; Intravenous; Movement; Pain; Rocuronium

MeSH Terms

Androstanols
Child
Humans
Incidence
Research Personnel
Unconsciousness
Androstanols